I 81 $north, I 81 $north; VA 100 $north
133.6 mi2 hours 1 min
| Head southwest on West Main Street (US 11) | 800 feet | |
| Turn left onto Cummings Street (US 58 Alternate) | 0.8 mi | |
| Take the ramp on the left onto US 58 Alternate | 0.2 mi | |
| Merge left onto I 81 N | 56.9 mi | |
| Continue onto I 77 S | 19.9 mi | |
| Continue onto I 81 N | 49.2 mi | |
| Take the ramp towards I 581: Airport | 0.3 mi | |
| Continue onto I 581 S | 5.4 mi | |
| Take the ramp towards US 11 South: Downtown | 600 feet | |
| Keep left onto US 220 Business | 0.4 mi | |
| Turn right onto Campbell Avenue Southeast (US 11) | 900 feet | |
| Turn left onto South Jefferson Street | 100 feet | |
| You have arrived at your destination |
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Abingdon, Virginia - Roanoke, Virginia