I 22 $west; US 78 $west, I 40
1,752.9 mi1 day 3 hours 46 mins
| Head southwest on County Road 324 | 0.7 mi | |
| Make a slight right to stay on County Road 324 | 0.7 mi | |
| Continue onto County Road 17 | 1.2 mi | |
| Turn right onto AL 22 | 1.4 mi | |
| Turn right onto SR 22 | 2.9 mi | |
| Turn left | 100 feet | |
| Go straight onto SR 191 | 13.9 mi | |
| Turn left onto US 31 | 10.3 mi | |
| Turn right onto 16th Avenue (SR 25) | 0.9 mi | |
| Take the ramp on the left | 0.2 mi | |
| Merge left onto I 65 N | 35.4 mi | |
| Take the ramp towards I 22 West: Memphis | 1.2 mi | |
| Continue onto I 22 W | 220.7 mi | |
| Take the ramp towards I 240: Nashville | 600 feet | |
| Keep left towards I 240 West: Saint Louis | 0.7 mi | |
| Merge left onto I 240 W | 4.1 mi | |
| Continue onto I 55 N | 5.5 mi | |
| Take the ramp towards I 55 North: Saint Louis | 7.9 mi | |
| Keep left onto I 40 | 442.7 mi | |
| Keep left onto Tinker Diagonal (I 40 W) | 12.3 mi | |
| Continue onto Crosstown Expressway (I 35 S) | 0.9 mi | |
| Keep right towards I 235 North: Oklahoma Health Center | 4.7 mi | |
| Continue towards I 40 West: Amarillo | 64.8 mi | |
| Continue onto Senator Ed Berrong Memorial Highway (I 40 W) | 2.6 mi | |
| Continue onto Korean War Veterans Memorial Highway (I 40 W) | 24.1 mi | |
| Continue onto Great Western Cattle Trail (I 40 W) | 10.6 mi | |
| Continue onto Korean War Veterans Memorial Highway (I 40 W) | 4.2 mi | |
| Turn right onto North Eastern Avenue | 200 feet | |
| Turn left onto East 3rd Street | 1.1 mi | |
| Make a slight left onto US Historic 66 | 6.6 mi | |
| Take the ramp towards I 40 West: Amarillo | 0.4 mi | |
| Merge left onto Korean War Veterans Memorial Highway (I 40 W) | 257.8 mi | |
| Continue onto I 40 | 487.3 mi | |
| Take the ramp towards I 17 South: Phoenix | 0.4 mi | |
| Keep left towards I 17: Sedona | 1.1 mi | |
| Merge left onto Arizona Veterans Highway (I 17 S) | 78.8 mi | |
| Take the ramp towards Bloody Basin Road | 0.3 mi | |
| Turn left onto Bloody Basin Road | 25.7 mi | |
| Turn left onto [FR 2007] | 1.4 mi | |
| Continue slightly left onto [FR 16] | 0.7 mi | |
| Turn right onto [FR 16A] | 1.0 mi | |
| Continue left onto [FR 16B] | 1.2 mi | |
| Turn right onto [FR 16] | 2.5 mi | |
| Keep left onto [FR 16] | 11.6 mi | |
| Turn right onto [FR 565] | 0.3 mi | |
| You have arrived at your destination |
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Alabama - Arizona