US 281 $north, I 10
794.3 mi12 hours 41 mins
| Head north on North Alamo Road (FM 907) | 0.5 mi | |
| Turn left onto West Expressway 83 | 0.4 mi | |
| Take the ramp on the left | 900 feet | |
| Merge left onto I 2 W | 2.7 mi | |
| Take the ramp towards I 69C North: Edinburg | 0.8 mi | |
| Continue onto I 69C N | 18.8 mi | |
| Continue onto US 281 N | 37.6 mi | |
| Turn right | 0.5 mi | |
| Turn left | 1.0 mi | |
| Turn right | 0.3 mi | |
| Turn left | 1.1 mi | |
| Turn right | 1.8 mi | |
| Turn left | 2.6 mi | |
| Turn right onto US 281 N | 10.6 mi | |
| Continue onto South Railroad Street | 1.5 mi | |
| Take the ramp | 900 feet | |
| Continue onto Fallifurias Expressway (US 281 N) | 90.4 mi | |
| Take the ramp onto US 281 N | 70.6 mi | |
| Take the ramp on the left towards I 35 South: Laredo | 0.4 mi | |
| Merge left onto North Pan-American Expressway (I 35 S) | 0 feet | |
| Keep right towards I 10: Upper Level | 1.0 mi | |
| Keep right at the fork | 0.4 mi | |
| Merge left onto McDermott Freeway (I 10) | 0.2 mi | |
| Keep right onto McDermott Freeway (I 10) | 13.1 mi | |
| Continue onto Interstate 10 West (I 10) | 522.5 mi | |
| Keep left onto I 10 | 14.1 mi | |
| Go straight onto East Yandell Drive | 0.5 mi | |
| Turn left onto North Mesa Street (TX 20) | 0.3 mi | |
| You have arrived at your destination |
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Alamo, Texas - El Paso, Texas