US 281 $north, I 35 $north
423.3 mi6 hours 27 mins
| Head west on East Main Street (TX 44) | 0.2 mi | |
| Continue onto East Front Street (TX 44) | 0.9 mi | |
| Turn right onto South Johnson Street | 800 feet | |
| Turn right onto US 281-R Business | 2.8 mi | |
| Go straight onto US 281-R Business | 900 feet | |
| Take the ramp on the right | 0.6 mi | |
| Merge left onto US 281 N | 51.2 mi | |
| Take the ramp onto US 281 N | 61.2 mi | |
| Take the ramp towards I 410 | 800 feet | |
| Keep right towards I 410 North | 0.5 mi | |
| Merge left onto Connally Loop (I 410 N) | 7.0 mi | |
| Take the ramp towards I 10: Downtown San Antonio | 600 feet | |
| Keep right towards I 10 East: Houston | 0.4 mi | |
| Keep left towards I 10 East: Houston | 900 feet | |
| Merge left onto 90th Infantry Division Highway (I 10) | 21.7 mi | |
| Continue onto I 10 | 10.9 mi | |
| Keep right towards TX Toll 130 North: Austin | 46.6 mi | |
| Keep left onto Pickle Parkway (TX 45 Toll N) | 7.8 mi | |
| Keep right onto Pickle Parkway (TX 45 Toll) | 11.2 mi | |
| Keep left onto Pickle Parkway (TX 45 Toll N) | 12.3 mi | |
| Keep right onto TX 130 Toll N | 9.8 mi | |
| Merge left onto I 35 N | 37.6 mi | |
| Keep left onto I 35 N | 32.3 mi | |
| Keep left onto Jack Kultgen Freeway (I 35 N) | 17.9 mi | |
| Keep left onto I 35 N | 16.8 mi | |
| Keep right towards I 35E: Dallas | 31.0 mi | |
| Keep left onto I 35E N | 25.3 mi | |
| Take the ramp towards I 30 East: Texarkana | 0.4 mi | |
| Keep left at the fork | 400 feet | |
| Keep right towards I 30 East: Texarkana | 0.4 mi | |
| Keep left towards I 30 East: Texarkana | 400 feet | |
| Merge left onto East R L Thornton Freeway (I 30) | 0.8 mi | |
| Take the ramp towards I 45 South: Houston | 0.5 mi | |
| Keep left towards US 75 North: McKinney | 0.5 mi | |
| Keep right at the fork | 0.3 mi | |
| Merge left onto Julius Schepps Freeway (I 345 N) | 0.8 mi | |
| Continue onto North Central Expressway (I 345 N) | 11.9 mi | |
| Take the ramp towards Arapaho Road | 1,000 feet | |
| Go straight onto Central Expressway | 0.6 mi | |
| Make a sharp left onto West Arapaho Road | 0.4 mi | |
| Turn left onto Civic Center Drive | 200 feet | |
| Turn right | 200 feet | |
| Turn right onto West Arapaho Road | 300 feet | |
| You have arrived at your destination |
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Alice, Texas - Richardson, Texas