I 99 $south; US 220 $south, I 70
311.5 mi6 hours 6 mins
| Head east on West Main Street (PA 607) | 300 feet | |
| Turn right onto PA 872 | 26.7 mi | |
| Turn right onto Main Street (PA 120) | 600 feet | |
| Turn left onto Wykoff Run Road | 9.9 mi | |
| Turn left onto Quehanna Highway | 8.7 mi | |
| Continue onto Frenchville Karthaus Highway (PA 879) | 2.6 mi | |
| Turn left onto Rolling Stone Road | 8.9 mi | |
| Continue onto Pine Street | 0.2 mi | |
| Turn right onto Kylertown Drifting Highway (PA 53) | 1.8 mi | |
| Keep left onto Morrisdale Allport Highway (PA 53) | 5.1 mi | |
| Continue onto Troy Hawk Run Highway (PA 53) | 1.1 mi | |
| Turn left onto Troy Hill Road | 200 feet | |
| Continue onto 9th Street | 0.3 mi | |
| Turn left onto Railroad Street (US 322) | 0.7 mi | |
| Continue onto Twenty-Eighth Division Highway (US 322) | 6.5 mi | |
| Continue onto Upper Flat Rock Road (US 322) | 1.6 mi | |
| Continue onto Flat Rock Road (US 322) | 1.5 mi | |
| Continue onto 28th Division Highway (US 322 E) | 0.3 mi | |
| Take the ramp towards US 220 Alternate: Port Matilda | 0.2 mi | |
| Continue onto North High Street | 0.6 mi | |
| Take the ramp on the right towards I 99 South: Altoona | 0.4 mi | |
| Merge left onto I 99 S | 60.6 mi | |
| Take the ramp towards Pittsburgh | 0.9 mi | |
| Turn right onto North Richard Street (US 220 Business) | 0.3 mi | |
| Take the ramp towards I 70: Pittsburgh | 1,000 feet | |
| Keep left towards I 76 East: Harrisburg | 0.3 mi | |
| Merge left onto Pennsylvania Turnpike (I 70) | 15.6 mi | |
| Take the ramp towards US 30: Breezewood | 1.9 mi | |
| Keep left towards US 30 West: Breezewood | 0.7 mi | |
| Turn left towards I 70 East: Baltimore | 75.9 mi | |
| Take the ramp towards Washington | 0.4 mi | |
| Continue onto Eisenhower Memorial Highway (I 270 N) | 22.9 mi | |
| Keep right onto I 270 S | 0.3 mi | |
| Continue onto I 270 N | 6.4 mi | |
| Keep right towards I 270 Spur: Washington | 2.0 mi | |
| Merge right onto Capital Beltway (I 495 W) | 1.2 mi | |
| Keep right towards Glen Echo | 1.8 mi | |
| Merge left onto Clara Barton Parkway | 0.7 mi | |
| Take the ramp on the left towards MacArthur Boulevard | 200 feet | |
| Merge right onto Clara Barton Parkway | 200 feet | |
| Take the ramp towards MacArthur Boulevard | 800 feet | |
| Turn right onto Macarthur Boulevard | 1.9 mi | |
| Continue onto Mac Arthur Boulevard | 0.3 mi | |
| Continue onto MacArthur Boulevard Northwest | 2.0 mi | |
| Continue onto Reservoir Road Northwest | 500 feet | |
| Turn right onto MacArthur Boulevard Northwest | 0.9 mi | |
| Continue onto Canal Road Northwest | 0.6 mi | |
| Keep right onto Whitehurst Freeway | 0.7 mi | |
| Keep right towards I 66 West: E Street | 0.4 mi | |
| Keep left onto Potomac Freeway | 0.5 mi | |
| Merge right onto Rock Creek and Potomac Parkway Northwest | 200 feet | |
| Merge left onto Ohio Drive Southwest | 0.2 mi | |
| Continue onto Independence Avenue Southwest | 0.8 mi | |
| Go straight onto Maine Avenue Southwest | 0.4 mi | |
| Take the ramp towards I 395 North | 0.5 mi | |
| Merge right onto Southwest Freeway (I 395 N) | 0.2 mi | |
| Keep left onto Southeast Freeway (I 695 E) | 0.3 mi | |
| Take the ramp towards South Capitol Street | 0.3 mi | |
| Continue onto South Capitol Street | 1.2 mi | |
| Keep left towards Suitland Parkway | 3.0 mi | |
| Turn right onto Naylor Road (MD 637) | 800 feet | |
| Enter the roundabout and take the 2nd exit onto Naylor Road (MD 637) | 100 feet | |
| Exit the roundabout onto Naylor Road (MD 637) | 400 feet | |
| Enter the roundabout and take the 2nd exit onto Naylor Road (MD 637) | 100 feet | |
| Exit the roundabout onto Naylor Road (MD 637) | 0.2 mi | |
| Merge left onto Branch Avenue (MD 5) | 0.3 mi | |
| Keep right onto Branch Avenue (MD 5) | 12.3 mi | |
| Merge right onto Crain Highway (US 301) | 2.2 mi | |
| Take the ramp on the left onto MD 5 | 3.2 mi | |
| Turn left onto Leonardtown Road (MD 5) | 7.8 mi | |
| Make a slight right onto Old Leonardtown Road (MD 5 Business) | 0.9 mi | |
| You have arrived at your destination |
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Austin, Pennsylvania - Hughesville, Maryland