William Penn Highway, I 99 $north; US 220 $north
226.5 mi4 hours 8 mins
| Head north on Library Avenue West | 0 feet | |
| Turn right | 100 feet | |
| Turn left onto Brightwood Road | 0.6 mi | |
| Turn left onto Library Road (PA 88) | 4.3 mi | |
| Turn left onto Saw Mill Run Boulevard (PA 51 N) | 2.3 mi | |
| Take the ramp | 600 feet | |
| Continue straight | 400 feet | |
| Turn right onto Liberty Tunnels | 1.2 mi | |
| Continue onto Liberty Bridge | 0.4 mi | |
| Take the ramp towards Oakland | 600 feet | |
| Keep right at the fork | 500 feet | |
| Continue onto Boulevard of the Allies (PA 885 S) | 1.0 mi | |
| Take the ramp towards I 376 East: Monroeville | 0.4 mi | |
| Merge right onto Penn-Lincoln Parkway East (I 376 E) | 12.3 mi | |
| Merge left onto William Penn Highway (US 22 E) | 1.6 mi | |
| Keep left onto William Penn Highway (US 22 E) | 43.1 mi | |
| Continue onto Admiral Peary Highway (US 22 E) | 13.6 mi | |
| Continue onto William Penn Highway (US 22 E) | 17.2 mi | |
| Keep left towards I 99 North: Altoona | 0.9 mi | |
| Merge left onto I 99 N | 44.9 mi | |
| Keep left towards Bellefonte | 12.0 mi | |
| Continue onto US 220 | 0.4 mi | |
| Turn left onto US 220 N | 0.3 mi | |
| Continue onto I 80 | 400 feet | |
| Continue onto I 80 N | 12.1 mi | |
| Take the ramp towards PA 64: Pleasant Gap | 0.4 mi | |
| Turn left onto Nittany Valley Drive (PA 64) | 4.2 mi | |
| Continue onto Fernberg Road (PA 64) | 0.4 mi | |
| Turn right onto PA 477 | 0.3 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto US 220 N | 27.6 mi | |
| Take the ramp towards US 15 North: Mansfield | 0.6 mi | |
| Merge left towards ||Third Street | 12.2 mi | |
| Take the ramp towards PA 14 North: Trout Run | 0.2 mi | |
| Go straight onto PA 14 N | 10.9 mi | |
| Turn right onto Green Street | 200 feet | |
| Turn right onto Holly Street | 800 feet | |
| Turn left onto Holly Street | 300 feet | |
| Turn right onto Dog Town Road | 800 feet | |
| You have arrived at your destination, on the left |
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Bethel Park, Pennsylvania - 17763, Ralston, Pennsylvania