I 81 $north, I 81 $north; US 11 $north
236.2 mi3 hours 49 mins
| Head southeast on East 5th Street North (US 23 Bus) | 0.3 mi | |
| Turn left onto Gilley Avenue East (US 58 Alt) | 1.2 mi | |
| Take the ramp onto US 58 Alternate E | 0.2 mi | |
| Merge left onto Orby Cantrell Highway (US 23 N) | 9.9 mi | |
| Take the ramp onto US 58 Alternate | 0.2 mi | |
| Turn right to stay on Norton Coeburn Road (US 58 Alternate) | 7.4 mi | |
| Continue onto Front Street West (US 58 Alternate) | 13.0 mi | |
| Continue onto Trail of the Lonesome Pine (US 58 Alternate) | 12.0 mi | |
| Continue onto US 58 Alternate | 2.9 mi | |
| Turn right onto US 19 | 1.1 mi | |
| Continue onto US 19 | 11.6 mi | |
| Turn left onto West Main Street (US 11) | 1.1 mi | |
| Turn right onto Cummings Street (US 58 Alternate) | 0.8 mi | |
| Take the ramp on the left onto US 58 Alternate | 0.2 mi | |
| Merge left onto I 81 N | 56.9 mi | |
| Continue onto I 77 S | 19.9 mi | |
| Continue onto I 81 N | 94.4 mi | |
| Take the ramp towards US 60 West: Lexington | 0.3 mi | |
| Go straight onto East Midland Trail (US 60) | 2.3 mi | |
| Continue onto East Nelson Street (US 60) | 0.5 mi | |
| Turn left onto South Randolph Street | 600 feet | |
| Turn right onto East Preston Street | 100 feet | |
| You have arrived at your destination, on the left |
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Big Stone Gap, Virginia - City of Lexington, Virginia