I 81 $north, I 64 $east; I 81 $north
321.8 mi5 hours 2 mins
| Head south on Virginia Avenue (US 19) | 200 feet | |
| Turn left to stay on Virginia Avenue (US 19) | 200 feet | |
| Turn right onto South College Avenue (SR 102) | 1.2 mi | |
| Go straight onto VA 720 | 0.3 mi | |
| Take the ramp on the right | 800 feet | |
| Merge left onto US 460 E | 5.3 mi | |
| Continue onto US 52 S | 0.7 mi | |
| Take the ramp onto US 52 Truck | 2.3 mi | |
| Take the ramp on the left onto US 52 | 19.7 mi | |
| Continue onto I 77 S | 7.2 mi | |
| Keep left towards I 77 South: Roanoke | 14.7 mi | |
| Continue onto I 81 N | 109.5 mi | |
| Continue onto I 64 E | 118.9 mi | |
| Take the ramp towards VA 7: Winchester | 0.2 mi | |
| Keep left at the fork | 300 feet | |
| Turn left onto Berryville Pike (VA 7) | 3.5 mi | |
| Continue onto Harry Flood Byrd Memorial Highway (VA 7) | 17.9 mi | |
| Continue onto Harry Flood Byrd Highway (VA 7) | 13.1 mi | |
| Continue onto Leesburg Bypass (VA 7) | 1.5 mi | |
| Take the ramp towards VA 7 East: Tysons Corner | 0.2 mi | |
| Merge left onto East Market Street (VA 7) | 2.1 mi | |
| Continue onto Harry Byrd Highway (VA 7) | 0.7 mi | |
| Continue onto Harry Flood Byrd Highway (VA 7) | 0.9 mi | |
| Take the ramp towards VA 901 South: Ashburn | 0.3 mi | |
| Go straight onto Claiborne Parkway (VA 901) | 0.3 mi | |
| Turn left onto Russell Branch Parkway (VA 1061) | 1,000 feet | |
| Turn right onto Ashburn Road (VA 641) | 0.8 mi | |
| You have arrived at your destination |
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Bluefield, Virginia - Ashburn, Virginia