I 40, US 60
890.1 mi14 hours 36 mins
| Head south on Main Street (US 21) | 0.3 mi | |
| Continue onto Wilson Boulevard (US 21) | 2.8 mi | |
| Take the ramp on the right towards I 77 South: Columbia | 0.3 mi | |
| Merge left onto I 77 S | 5.3 mi | |
| Keep right onto SC 277 S | 1.7 mi | |
| Take the ramp towards I 20 West: Augusta | 0.4 mi | |
| Merge left onto I 20 | 8.3 mi | |
| Take the ramp towards I 26 West: Spartanburg | 0.5 mi | |
| Merge left onto I 26 W | 133.6 mi | |
| Continue onto I 26 W | 12.7 mi | |
| Take the ramp on the left towards I 40 West: Canton | 129.7 mi | |
| Keep right towards Nashville | 154.6 mi | |
| Keep right towards I 24 West: Nashville | 2.1 mi | |
| Keep right towards I 24 West: Clarksville | 4.8 mi | |
| Keep left towards I 24 West: Clarksville | 112.6 mi | |
| Keep right onto I 24 W | 21.0 mi | |
| Take the ramp towards US 60: Paducah | 1,000 feet | |
| Keep left towards US 60: Paducah | 0.3 mi | |
| Merge left onto Old Hinkleville Road (US 60) | 10.5 mi | |
| Continue onto Paducah Rd (US 60) | 6.1 mi | |
| Continue onto West Kentucky Avenue (US 60) | 0.5 mi | |
| Continue onto Paducah Road (US 60) | 3.2 mi | |
| Continue onto Broadway (US 60) | 0.6 mi | |
| Turn left onto South 4th Street (US 60) | 0.2 mi | |
| Continue onto Main Street (US 60) | 5.9 mi | |
| Go straight onto Lee Street (US 60) | 700 feet | |
| Continue onto 4th Street (US 60) | 0.2 mi | |
| Turn right onto Green Street (US 51) | 4.8 mi | |
| Turn right to stay on US 51 | 5.2 mi | |
| Take the ramp on the right | 0.4 mi | |
| Merge left onto I 57 S | 69.0 mi | |
| Keep left onto US 60 | 5.5 mi | |
| Take the ramp towards US 60 West: Springfield | 4.5 mi | |
| Keep right onto US 60 | 104.3 mi | |
| Keep left towards US 60 West: Mountain Grove | 68.1 mi | |
| Take the ramp towards US 65 North: Sedalia | 0.3 mi | |
| Merge left onto Schoolcraft Freeway (US 65 N) | 5.3 mi | |
| Take the ramp towards US 65 Business | 0.3 mi | |
| Turn left towards US 65 Business | 200 feet | |
| Turn left onto East Chestnut Expressway | 1.5 mi | |
| Make a slight left onto E Trafficway Street | 1.2 mi | |
| Turn left onto North National Avenue | 400 feet | |
| Turn right onto East Saint Louis Avenue | 0.8 mi | |
| Continue onto Park Central East | 500 feet | |
| You have arrived at your destination |
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Blythewood, South Carolina - Springfield, Missouri