I 77 $north, I 81 $north
633.5 mi9 hours 57 mins
| Head southeast on West King Street (US 321) | 3.1 mi | |
| Continue onto US 221 | 26.5 mi | |
| Continue onto US 421 | 1.1 mi | |
| Continue onto US 421 S | 22.6 mi | |
| Take the ramp towards I 77 North: Elkin | 0.2 mi | |
| Merge left onto I 77 N | 9.9 mi | |
| Keep right onto I 77 N | 54.1 mi | |
| Take the ramp towards I 81 North: Roanoke | 0.5 mi | |
| Merge left towards I 81 North: Roanoke | 12.0 mi | |
| Continue onto I 81 N | 102.5 mi | |
| Continue onto I 64 E | 254.1 mi | |
| Keep left towards I 81 North: Hazleton | 97.7 mi | |
| Take the ramp towards I-84 east | 0.4 mi | |
| Keep left at the fork | 0.3 mi | |
| Keep right towards I 84 East: Mt Pocono | 0.4 mi | |
| Continue onto I 84 E | 3.4 mi | |
| Take the ramp on the left towards I 84 East: Milford | 42.2 mi | |
| Take the ramp towards US 6: Milford | 0.3 mi | |
| Keep right at the fork | 300 feet | |
| Merge left onto Grand Army of the Republic Highway (US 6 E) | 1.6 mi | |
| Continue onto West Harford Street (US 6 E) | 0.5 mi | |
| Turn left onto Broad Street (US 6 E) | 100 feet | |
| You have arrived at your destination |
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Boone, North Carolina - Milford, Pennsylvania