US 281, Highway 81
370.5 mi6 hours 13 mins
| Head south on 6th Street | 0 feet | |
| Turn right onto Maple Street (OK 8) | 3.6 mi | |
| Turn right onto OK 8 | 6.9 mi | |
| Continue onto KS 8 | 1.3 mi | |
| Turn left onto Main Street (KS 2 W) | 4.5 mi | |
| Turn right onto US 281 | 18.0 mi | |
| Turn right to stay on US 160 | 0.6 mi | |
| Turn left onto South Iliff Street (US 281) | 29.0 mi | |
| Continue onto South Main Street (US 281) | 0.7 mi | |
| Turn right onto East 1st Street (US 54 E) | 1.3 mi | |
| Turn left onto KS 61 | 44.2 mi | |
| Take the ramp on the right towards Hutchinson | 9.4 mi | |
| Take the ramp towards KS 61 North | 0.3 mi | |
| Turn left onto South Lorraine Street (KS 61) | 1.1 mi | |
| Continue onto Ken Kennedy Freeway (KS 61) | 28.4 mi | |
| Take the ramp on the left | 0.2 mi | |
| Merge left onto I 135 N | 175.6 mi | |
| Turn left towards I 80 west | 0.3 mi | |
| Merge left onto I 80 | 34.2 mi | |
| Take the ramp towards NE 2: Grand Island | 0.4 mi | |
| Turn right onto Highway 2 (NE 2) | 3.3 mi | |
| Turn left onto Highway 34 (US 34) | 3.6 mi | |
| Turn right onto South Stuhr Road | 2.0 mi | |
| Turn left onto East Bismark Road | 0.2 mi | |
| Turn right onto South Cherry Street | 0.7 mi | |
| Continue slightly right onto South Plum Street | 0.3 mi | |
| Turn left onto East 2nd Street (US 30R) | 0.4 mi | |
| You have arrived at your destination |
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Burlington, Oklahoma - Grand Island, Nebraska