I 57 $north; US 51 $north, I 57 $north
373.1 mi6 hours 10 mins
| Head northwest on Washington Avenue (US 51) | 300 feet | |
| Continue onto Sycamore Street (US 51) | 3.0 mi | |
| Take the ramp on the right onto US 51 N | 57.0 mi | |
| Continue onto I 57 N | 105.1 mi | |
| Keep left towards I 57 North: Chicago | 155.0 mi | |
| Keep left onto I 57 N | 39.7 mi | |
| Keep left towards I 94 West: Chicago Loop | 0.7 mi | |
| Continue onto Dan Ryan Expressway (I 94 W) | 3.3 mi | |
| Keep left towards I 90 Express | 7.9 mi | |
| Continue onto Kennedy Expressway (I 90 W) | 0.3 mi | |
| Take the ramp towards Washington Boulevard East (100 North) | 900 feet | |
| Turn right onto West Washington Street | 0.7 mi | |
| Turn left onto North LaSalle Street | 400 feet | |
| You have arrived at your destination |
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Cairo, Illinois - Chicago, Illinois