William Penn Highway, Big Valley Pike
163.6 mi3 hours 23 mins
| Head east on East Pike Street (PA 980) | 0.2 mi | |
| Continue onto Adams Avenue (PA 980) | 0.2 mi | |
| Turn right onto Morganza Road | 0.4 mi | |
| Turn right onto Old Pike Street | 700 feet | |
| Continue onto McClelland Road | 800 feet | |
| Take the ramp on the left | 0.3 mi | |
| Merge right onto I 79 N | 12.6 mi | |
| Take the ramp towards I 376 East: Pittsburgh | 0.5 mi | |
| Merge left onto Penn-Lincoln Parkway West (I 376 E) | 5.7 mi | |
| Keep right towards I 376 East: Monroeville | 14.7 mi | |
| Merge left onto William Penn Highway (US 22 E) | 1.6 mi | |
| Keep left onto William Penn Highway (US 22 E) | 43.1 mi | |
| Continue onto Admiral Peary Highway (US 22 E) | 13.6 mi | |
| Continue onto William Penn Highway (US 22 E) | 16.4 mi | |
| Take the ramp towards US 22 East: Hollidaysburg | 0.9 mi | |
| Keep left towards PA 764 North: Altoona | 0.5 mi | |
| Merge left onto PA 764 N | 0.3 mi | |
| Turn right onto Carson Valley Road | 600 feet | |
| Turn right onto Colonial Drive | 0.2 mi | |
| Continue slightly left onto Municipal Drive | 1.1 mi | |
| Continue onto North Juniata Street | 1.1 mi | |
| Turn left onto South Juniata Street (US 22 E) | 600 feet | |
| Continue onto Blair Street (US 22 E) | 32.9 mi | |
| Turn left onto Big Valley Pike (PA 655) | 16.6 mi | |
| You have arrived at your destination |
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Canonsburg, Pennsylvania - Belleville, Pennsylvania