US 51, 675E
47.0 mi1 hour 9 mins
| Head west on East Main Street (IL 13) | 800 feet | |
| Turn left onto South University Avenue (US 51) | 0.5 mi | |
| Continue slightly left onto South Illinois Avenue (US 51) | 8.9 mi | |
| Continue onto 1575E (US 51) | 2.4 mi | |
| Continue onto 1615E (US 51) | 7.2 mi | |
| Turn right onto Vienna Street (IL 146) | 1.1 mi | |
| Turn left onto Broad Street (IL 146) | 1.4 mi | |
| Turn left to stay on Public Square | 200 feet | |
| Make a slight right onto West Broad Street (IL 127) | 1,000 feet | |
| Continue onto Willards Ferry Road (IL 127) | 0.5 mi | |
| Go straight onto 1325E (IL 127) | 2.8 mi | |
| Continue onto 825N (IL 146) | 0.7 mi | |
| Continue onto 1050E (IL 146) | 1.7 mi | |
| Continue onto 785N (IL 146) | 1.9 mi | |
| Turn left to stay on State Route 3 South (IL 3) | 1.9 mi | |
| Continue onto 675E (IL 3) | 8.0 mi | |
| Continue onto Illinois State Route 3 (IL 3) | 1.7 mi | |
| Turn right onto IL 146 W | 4.1 mi | |
| Turn right onto South Fountain Street | 0.2 mi | |
| Enter the roundabout and take the 3rd exit onto Morgan Oak Street (MO 177) | 200 feet | |
| Exit the roundabout onto Morgan Oak Street (MO 177) | 0.3 mi | |
| Turn right onto South Sprigg Street | 0.2 mi | |
| Turn left onto William Street | 0.9 mi | |
| You have arrived at your destination |
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Carbondale, Illinois - Cape Girardeau, Missouri