US 22 $west; US 322 $west, US 322 $west
103.0 mi1 hour 53 mins
| Head north on South Hanover Street (PA 34) | 100 feet | |
| Turn right onto East High Street (PA 74) | 0.9 mi | |
| Continue onto West Trindle Road (PA 641) | 0.7 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge right onto I 81 N | 17.1 mi | |
| Take the ramp towards Downtown Harrisburg | 0.2 mi | |
| Keep left at the fork | 0.3 mi | |
| Go straight onto Front Street | 0.9 mi | |
| Turn right onto Linglestown Road (PA 39) | 0.5 mi | |
| Turn left towards US 22 West: Lewistown | 700 feet | |
| Take the ramp towards US 22 West: Lewistown | 0.2 mi | |
| Merge left onto US 22 W | 76.7 mi | |
| Take the ramp towards US 322 Business: Boalsburg | 1.7 mi | |
| Continue onto South Atherton Street (US 322 Business W) | 2.4 mi | |
| Turn right onto Old Boalsburg Road | 0.4 mi | |
| Turn left to stay on Old Boalsburg Road | 500 feet | |
| Go straight onto South Allen Street | 0.5 mi | |
| You have arrived at your destination |
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Carlisle, Pennsylvania - State College, Pennsylvania