How to get from Charles City, Iowa to Desoto, Missouri

Discover, print or download the driving directions for the best route to go from Charles City, Iowa to Desoto, Missouri.

Enlarge the route map Charles City, Iowa - Desoto, Missouri

Driving directions from Charles City, Iowa to Desoto, Missouri

Avenue of the Saints, Avenue of the Saints

413.8 mi6 hours 53 mins

Head southwest on Brantingham Street (US 18) 0.3 mi
Turn left onto Gilbert Street (US 18) 400 feet
Continue onto South Grand Avenue (US 18) 0.9 mi
Continue onto Shadow Avenue (US 18) 0.9 mi
Take the ramp on the left onto US 218 Business 0.3 mi
Merge left onto Avenue of the Saints (US 218 S) 41.2 mi
Take the ramp towards US 218 south: Waterloo 300 feet
Continue towards US 218 south: Waterloo 0.3 mi
Merge left onto Leo P Rooff Expressway (US 218 S) 6.7 mi
Continue onto Washington Street (US 218 S) 2.4 mi
Take the ramp towards I-380 south: Cedar Rapids 0.2 mi
Keep left towards I-380 south: Cedar Rapids 6.3 mi
Take the ramp towards I 380 South: Cedar Rapids 49.2 mi
Continue onto I 380 S 156.6 mi
Keep left towards US 61 South: Hannibal 6.7 mi
Continue onto McMasters Avenue (US 61 S) 1.1 mi
Continue onto Avenue of the Saints (US 61) 0.7 mi
Continue onto McMasters Avenue (US 61 S) 1.6 mi
Continue onto Avenue of the Saints (US 61 S) 95.6 mi
Take exit 22 towards MO 141 0.3 mi
Turn right onto MO 141 S 15.0 mi
Take the ramp 0.2 mi
Merge left onto MO 21 19.8 mi
Keep left at the fork 100 feet
Turn left onto MO 21 0.5 mi
Turn right to stay on MO 21 3.8 mi
Turn left onto MO 110 1.6 mi
Turn right onto North Main Street 1.4 mi
Turn right onto Easton Street 400 feet
You have arrived at your destination, on the right

Print directions
Charles City, Iowa - Desoto, Missouri

At How to get from we offer the best route to any destination. We use the most advanced technologies of maps representation, route calculation, traffic information updated in real time and distance calculator to give you a detailed itinerary to get to your destination.