I 95 $south, I 75 $south
573.6 mi9 hours 25 mins
| Head north on Meeting Street (S-10-107) | 0.4 mi | |
| Turn left onto Calhoun Street | 1.0 mi | |
| Take the ramp onto SC 30 W | 0.2 mi | |
| Continue onto James Island Expressway | 0.3 mi | |
| Take the ramp onto SC 61 | 1.2 mi | |
| Turn left onto Wesley Drive | 500 feet | |
| Turn right onto Savannah Highway (US 17) | 28.7 mi | |
| Continue onto Ace Basin Parkway (US 17) | 17.1 mi | |
| Continue onto Charleston Highway (US 17) | 12.4 mi | |
| Continue onto Castle Hall Road (US 17) | 0.3 mi | |
| Continue onto Kings Highway (US 17) | 148.1 mi | |
| Continue onto I 95 S | 18.7 mi | |
| Take the ramp towards I 295 West Beltway: Orange Park | 0.6 mi | |
| Continue onto I 295 S | 13.8 mi | |
| Take the ramp towards I-10 West | 0.4 mi | |
| Merge left onto I 10 W | 12.6 mi | |
| Take the ramp towards US 301: Baldwin | 0.2 mi | |
| Keep right at the fork | 600 feet | |
| Merge left onto US 301 | 36.7 mi | |
| Keep left onto Sid Martin Highway (US 301) | 39.1 mi | |
| Turn right onto Northwest 70th Street (FL 326) | 1.7 mi | |
| Continue onto NW 77th Street (FL 326) | 0.9 mi | |
| Continue onto CR 326 | 0.2 mi | |
| Take the ramp on the left | 0 feet | |
| Turn left onto CR 326 | 1,000 feet | |
| Take the ramp | 0.3 mi | |
| Merge left onto I 75 S | 29.1 mi | |
| Keep right towards I 75 South: Tampa | 53.5 mi | |
| Keep left towards South I 75: Naples | 16.2 mi | |
| Continue onto I 75 S | 58.3 mi | |
| Keep left onto I 75 S | 42.2 mi | |
| Take the ramp towards Tuckers Grade | 0.3 mi | |
| Keep left at the fork | 300 feet | |
| Turn right onto Tuckers Grade (CR 762) | 1.0 mi | |
| Turn left onto Tamiami Trail (US 41) | 11.4 mi | |
| Continue onto North Cleveland Avenue (US 41) | 5.5 mi | |
| Turn right onto McGregor Boulevard | 10.0 mi | |
| Turn right to stay on McGregor Boulevard (CR 867) | 4.8 mi | |
| Continue onto Sanibel Causeway Boulevard (Span A) | 2.8 mi | |
| Continue onto Causeway Road | 0.4 mi | |
| Turn right onto Periwinkle Way | 2.2 mi | |
| Turn right onto Dunlop Road | 700 feet | |
| You have arrived at your destination |
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Charleston, South Carolina - Sanibel, Florida