MS 12, US 49
109.1 mi2 hours 28 mins
| Head east on Eastside Lake Washington Road | 0.7 mi | |
| Turn left | 300 feet | |
| Turn right onto Roy's Store Road | 1.3 mi | |
| Turn left onto MS 1 | 2.0 mi | |
| Turn right onto Riverside Road | 3.3 mi | |
| Turn right onto MS 12 | 9.6 mi | |
| Turn right onto East Avenue South (MS 12) | 800 feet | |
| Turn left onto East Crouch Street (MS 12) | 21.1 mi | |
| Turn right onto US 49W | 23.6 mi | |
| Keep right onto US 49W | 0.5 mi | |
| Merge right onto Jerry Clower Boulevard (US 49) | 2.8 mi | |
| Make a slight right onto Jerry Clower Blvd N (US 49) | 36.1 mi | |
| Continue onto Medgar Evers Boulevard | 0.3 mi | |
| Take the ramp on the left | 0.4 mi | |
| Merge left onto I 220 N | 5.8 mi | |
| Keep left towards I 55 North | 0.7 mi | |
| Merge left onto I 55 N | 0.2 mi | |
| Take exit 105A towards NTP | 0.5 mi | |
| Turn right onto Natchez Trace Parkway | 100 feet | |
| You have arrived at your destination |
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Chatham, Mississippi - Ridgeland, Mississippi