I 74 $east, I 26 $east
1,352.2 mi20 hours 56 mins
| Head south on South 2nd Street (US 59) | 17.1 mi | |
| Continue onto North Main Street (US 59) | 2.0 mi | |
| Take the ramp on the left onto US 59 S | 8.0 mi | |
| Continue onto 220th Street (US 20 E) | 165.5 mi | |
| Take the ramp towards I 380 South: Cedar Rapids | 49.2 mi | |
| Continue onto I 380 S | 16.1 mi | |
| Take the ramp towards I 80 East: Iowa City | 0.3 mi | |
| Merge left onto I 80 | 182.9 mi | |
| Continue onto I 74 E | 7.5 mi | |
| Keep right towards I 55 South | 6.4 mi | |
| Keep left towards I 74 East: Indianapolis | 80.8 mi | |
| Take the ramp towards US 150 | 1,000 feet | |
| Keep left towards US 150 West | 1,000 feet | |
| Keep left towards I 74 East | 0.3 mi | |
| Merge left onto I 74 E | 85.4 mi | |
| Continue onto I 74 | 0.4 mi | |
| Continue onto I 74 E | 8.3 mi | |
| Take exit 53B towards I 65 South: Louisville | 0.5 mi | |
| Merge left onto I 65 S | 106.2 mi | |
| Take the ramp towards I 64: Lexington | 100 feet | |
| Keep left towards I 64 East: Lexington | 0.8 mi | |
| Merge left onto I 64 E | 175.4 mi | |
| Continue onto I 75 S | 64.6 mi | |
| Continue onto I 275 S | 0.3 mi | |
| Take the ramp towards I 640 East: Asheville | 0.2 mi | |
| Merge left onto I 640 E | 6.7 mi | |
| Keep left towards I 40 East: Asheville | 28.5 mi | |
| Keep right towards I 40 East: Asheville | 76.3 mi | |
| Take the ramp towards I 26 East: Hendersonville | 13.3 mi | |
| Continue onto I 26 E | 134.6 mi | |
| Keep right towards Charleston | 112.6 mi | |
| Take the ramp on the left towards Visitor Center | 0.4 mi | |
| Turn right onto Meeting Street (US 52) | 1.2 mi | |
| You have arrived at your destination |
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Cherokee, Iowa - Charleston, South Carolina