US 35 $west, I 71 $south
104.6 mi1 hour 43 mins
| Head west on East Main Street | 1.1 mi | |
| Turn right onto North High Street (SR 104) | 1.5 mi | |
| Take the ramp on the left towards US 35 West: Dayton | 800 feet | |
| Merge left onto US 35 W | 37.6 mi | |
| Take exit 72 towards SR 435: Columbus | 0.3 mi | |
| Turn left onto Old United States Highway 35 (SR 435) | 0.9 mi | |
| Turn left towards I 71 South: Cincinnati | 0.3 mi | |
| Merge left onto I 71 S | 28.7 mi | |
| Continue onto I 71 W | 3.5 mi | |
| Continue onto I 71 S | 28.6 mi | |
| Take exit 3A towards Taft Road | 800 feet | |
| Keep left towards Taft Road | 0.8 mi | |
| Turn right onto William Howard Taft Road | 0.7 mi | |
| Continue onto Calhoun Street | 1,000 feet | |
| Turn left onto Ohio Avenue | 300 feet | |
| You have arrived at your destination, on the left |
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Chillicothe, Ohio - Cincinnati, Ohio