I 26 $east, I 95 $south
152.9 mi2 hours 25 mins
| Head north on Huger Street (US 21) | 100 feet | |
| Make a U-turn and continue on Huger Street (US 21) | 500 feet | |
| Turn right onto Gervais Street (US 1) | 0.5 mi | |
| Continue onto Meeting Street (US 1) | 1.2 mi | |
| Turn left | 100 feet | |
| Go straight onto Charleston Highway | 0.8 mi | |
| Turn right onto Charleston Highway (US 21) | 0.5 mi | |
| Make a slight right onto Airport Boulevard (SC 302) | 1.4 mi | |
| Take the ramp on the left | 800 feet | |
| Merge left onto I 26 E | 54.7 mi | |
| Take the ramp towards I 95 South: Savannah | 0.9 mi | |
| Merge left onto I 95 S | 76.9 mi | |
| Take the ramp towards US 278: Hardeeville | 0.2 mi | |
| Keep left towards US 278 East: Sun City | 300 feet | |
| Continue left onto Independence Boulevard (US 278) | 6.3 mi | |
| Continue onto Fording Island Road (US 278) | 7.4 mi | |
| Turn right onto Bluffton Road (SC 46) | 0.8 mi | |
| Enter the roundabout and take the 2nd exit onto Bluffton Road (SC 46) | 200 feet | |
| Exit the roundabout onto Bluffton Road (SC 46) | 0.9 mi | |
| Turn right onto May River Road (SC 46) | 200 feet | |
| You have arrived at your destination |
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Columbia, South Carolina - Bluffton, South Carolina