I 75 $south, I 16 $east
544.5 mi8 hours 20 mins
| Head north on North Garden Street (US 31) | 0.4 mi | |
| Continue onto Nashville Highway (US 31) | 1.4 mi | |
| Turn right onto Bear Creek Pike (US 412) | 7.2 mi | |
| Take the ramp | 900 feet | |
| Merge left onto I 65 N | 7.0 mi | |
| Keep left onto I 65 N | 5.5 mi | |
| Take exit 59A-B towards 840 | 0.2 mi | |
| Keep right towards 840: Knoxville | 0.5 mi | |
| Merge left onto I 840 E | 21.1 mi | |
| Take exit 53A towards 24: Chattanooga | 0.8 mi | |
| Merge left onto I 24 E | 110.0 mi | |
| Keep right towards Atlanta | 0.4 mi | |
| Merge left onto I 75 S | 111.0 mi | |
| Continue onto James Wendell George Parkway (I 75 S) | 2.3 mi | |
| Keep left onto I 75 S | 77.6 mi | |
| Take the ramp on the left towards I 16 East: Savannah | 156.7 mi | |
| Take the ramp towards I 95 North: Airport | 0.3 mi | |
| Merge left onto I 95 N | 21.2 mi | |
| Take the ramp towards US 278: Beaufort | 0.3 mi | |
| Keep right towards US 278 East: Beaufort | 400 feet | |
| Merge left onto Independence Boulevard (US 278) | 6.0 mi | |
| Continue onto Fording Island Road (US 278) | 10.9 mi | |
| Continue onto William Hilton Parkway (US 278) | 3.4 mi | |
| You have arrived at your destination |
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Columbia, Tennessee - Hilton Head, South Carolina