I 80, I 35 $south
425.5 mi6 hours 36 mins
| Head south on Main Street (WI 23) | 0.2 mi | |
| Continue onto Galena Street (WI 23) | 0.9 mi | |
| Turn right onto State Highway 81 (WI 81) | 15.7 mi | |
| Turn right onto State Highway 80 (WI 80) | 3.7 mi | |
| Turn left | 0.3 mi | |
| Merge left onto US 151 | 26.9 mi | |
| Take the ramp onto US 151 S | 56.9 mi | |
| Turn left onto US 151 S | 7.5 mi | |
| Keep right onto US 151 S | 6.8 mi | |
| Take the ramp towards I 380 South: Iowa City | 0.3 mi | |
| Merge left onto I 380 S | 0.3 mi | |
| Continue onto I 380 S | 15.6 mi | |
| Take the ramp towards I 80 West: Des Moines | 0.6 mi | |
| Merge left onto I 80 | 252.7 mi | |
| Continue onto I 35 S | 34.5 mi | |
| Keep right towards US 69 South: Pleasant Valley | 2.4 mi | |
| You have arrived at your destination |
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Darlington, Wisconsin - Claycomo, Missouri