How to get from Des Moines, Iowa to Lexington, Kentucky

Discover, print or download the driving directions for the best route to go from Des Moines, Iowa to Lexington, Kentucky.

Enlarge the route map Des Moines, Iowa - Lexington, Kentucky

Driving directions from Des Moines, Iowa to Lexington, Kentucky

I 80, I 74 $east

661.2 mi10 hours 8 mins

Head east on East Grand Avenue 1.1 mi
Turn left onto East 15th Street (US 69) 800 feet
Take the ramp on the right towards I-235 east 0.7 mi
Merge left onto I 235 E 3.3 mi
Take exit 137 towards I 35 South: Kansas City 0.3 mi
Keep right towards I 80 East: Davenport 0.3 mi
Merge left onto I 80 283.6 mi
Continue onto I 74 E 7.5 mi
Keep right towards I 55 South 6.4 mi
Keep left towards I 74 East: Indianapolis 80.8 mi
Take the ramp towards US 150 1,000 feet
Keep left towards US 150 West 1,000 feet
Keep left towards I 74 East 0.3 mi
Merge left onto I 74 E 85.4 mi
Continue onto I 74 0.4 mi
Continue onto I 74 E 8.3 mi
Take exit 53B towards I 65 South: Louisville 0.5 mi
Merge left onto I 65 S 106.2 mi
Take the ramp towards I 64: Lexington 100 feet
Keep left towards I 64 East: Lexington 0.8 mi
Merge left onto I 64 E 70.9 mi
Take the ramp towards Bluegrass Parkway : Airport 0.3 mi
Turn right onto Newtown Pike (KY 922) 3.3 mi
Turn left onto West Main Street (US 25) 0.4 mi
Continue onto West Vine Street (US 25) 800 feet
Turn left onto South Broadway (US 27) 200 feet
You have arrived at your destination

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Des Moines, Iowa - Lexington, Kentucky

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