Dwight D. Eisenhower Highway, I 40
1,447.4 mi21 hours 14 mins
| Head west on West Center Street (I 25 Business) | 200 feet | |
| Make a U-turn and continue on West Center Street (I 25 Business) | 400 feet | |
| Turn right onto South 4th Street (I 25 Business) | 0.8 mi | |
| Turn left onto East Richards Street (I 25 Bus) | 2.4 mi | |
| Take the ramp on the right onto I 25 Bus | 400 feet | |
| Keep left onto I 25 Bus | 0.7 mi | |
| Merge left onto I 25 S | 8.2 mi | |
| Continue onto I 25 S | 34.1 mi | |
| Continue towards Cheyenne | 75.6 mi | |
| Continue onto I 25 S | 87.7 mi | |
| Take exit 228 towards Northwest Parkway: Broomfield | 0.2 mi | |
| Keep left towards E 470 Toll: Limon | 0.8 mi | |
| Merge left onto E-470 | 24.6 mi | |
| Take exit 20 towards I 70: Aurora | 0.7 mi | |
| Continue onto Gun Club Road | 0.2 mi | |
| Turn left towards I 70 East: Limon | 0.3 mi | |
| Merge left onto I 70 E | 159.9 mi | |
| Continue onto I 70 | 250.0 mi | |
| Take the ramp towards I 135 South: Wichita | 0.4 mi | |
| Merge left onto I 135 S | 63.0 mi | |
| Continue onto I 135 S | 32.5 mi | |
| Keep right towards I 35 South: Oklahoma City | 0.3 mi | |
| Merge left onto Kansas Turnpike (I 35 S) | 25.1 mi | |
| Take the ramp on the left towards Toll Plaza | 0.2 mi | |
| Merge right onto Kansas Turnpike (I 35 S) | 16.6 mi | |
| Continue onto World War II Veterans Memorial Highway (I 35 S) | 41.7 mi | |
| Take exit 194A towards US 412 East: Tulsa | 1,000 feet | |
| Merge left onto Norma A. Lamb Highway (US 412) | 200 feet | |
| Continue onto Cimarron Turnpike (US 412) | 14.6 mi | |
| Keep straight onto Cimarron Turnpike (US 412) | 44.7 mi | |
| Continue onto Keystone Expressway (US 64 E) | 9.5 mi | |
| Continue onto Sand Springs Expressway (US 64 E) | 14.4 mi | |
| Keep left onto US 412 | 0.5 mi | |
| Merge right onto Martin Luther King, Junior Memorial Expressway (I 244 E) | 7.6 mi | |
| Take exit 13B towards US 169 South | 0.4 mi | |
| Merge left onto Pearl Harbor Memorial Expressway (US 169 S) | 1.3 mi | |
| Continue onto Representative Sue Tibbs Memorial Highway (US 169 S) | 3.1 mi | |
| Take the ramp towards OK 51 East: Broken Arrow | 900 feet | |
| Merge left onto Broken Arrow Expressway (OK 51) | 2.9 mi | |
| Continue onto Disabled American Veterans Highway (OK 51) | 3.8 mi | |
| Continue onto Muskogee Turnpike (OK 351 E) | 11.6 mi | |
| Take the ramp towards Cash and all exiting traffic | 700 feet | |
| Keep left towards OK 351 East: Cash Customers | 500 feet | |
| Keep right towards Cash Vehicles | 0.3 mi | |
| Merge left onto Muskogee Turnpike (OK 351 E) | 28.8 mi | |
| Keep left onto Muskogee Turnpike (OK 351) | 14.5 mi | |
| Keep left towards I 40 East: Fort Smith | 0.9 mi | |
| Merge left onto Vietnam Veteran's Memorial Highway (I 40 E) | 196.9 mi | |
| Take the ramp onto US 65 S | 4.7 mi | |
| Keep left onto I 530 S | 35.0 mi | |
| Take the ramp onto US 65B S | 8.7 mi | |
| Keep right onto US 65B | 900 feet | |
| Keep left onto US 65B | 0.6 mi | |
| Merge left onto I 530 S | 200 feet | |
| Continue onto US 65 | 123.5 mi | |
| Turn right onto North Martin Luther King Drive (US 49W) | 46.3 mi | |
| Keep right onto US 49W | 0.5 mi | |
| Merge right onto Jerry Clower Boulevard (US 49) | 2.8 mi | |
| Make a slight right onto Jerry Clower Blvd N (US 49) | 36.1 mi | |
| Continue onto Medgar Evers Boulevard | 3.4 mi | |
| Take the ramp on the left | 100 feet | |
| Merge right onto West Woodrow Wilson Avenue | 1.2 mi | |
| Turn right onto North State Street (US 51) | 2.0 mi | |
| You have arrived at your destination |
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Douglas, Wyoming - Jackson, Mississippi