James L Gillis Sr Memorial Highway, I 16 $east
155.8 mi2 hours 31 mins
| Head east on Bellevue Avenue (US 80) | 100 feet | |
| Continue onto West Jackson Street (US 80) | 900 feet | |
| Turn right onto South Jefferson Street (US 441) | 0.4 mi | |
| Continue onto Martin Luther King Jr Drive (19) | 1.5 mi | |
| Continue onto Glenwood Avenue (19) | 0.6 mi | |
| Continue onto Martin Luther King Jr Drive (19) | 1.5 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto James L Gillis Sr Memorial Highway (I 16 E) | 103.1 mi | |
| Take the ramp towards I 95 North: Airport | 0.3 mi | |
| Merge left onto I 95 N | 21.2 mi | |
| Take the ramp towards US 278: Beaufort | 0.3 mi | |
| Keep right towards US 278 East: Beaufort | 400 feet | |
| Merge left onto Independence Boulevard (US 278) | 6.0 mi | |
| Continue onto Fording Island Road (US 278) | 10.9 mi | |
| Continue onto William Hilton Parkway (US 278) | 3.8 mi | |
| Keep left onto Cross Island Parkway (US 278 E) | 5.6 mi | |
| Go straight onto US 278 | 200 feet | |
| Enter Sea Pines Circle and take the 2nd exit | 300 feet | |
| Exit the roundabout | 100 feet | |
| You have arrived at your destination |
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Dublin, Georgia - Hilton Head Island, South Carolina