I 40, I 22 $east; US 78 $east
936.7 mi15 hours 31 mins
| Head southwest on South Main Street (AR 23) | 0.6 mi | |
| Turn left onto East Van Buren Street (US 62) | 0.7 mi | |
| Turn right onto Huntsville Road (Hwy 23) | 0.6 mi | |
| Continue onto Van Buren Street (Hwy 23) | 6.7 mi | |
| Continue onto AR 23 | 5.1 mi | |
| Turn right onto AR 23 | 13.3 mi | |
| Go straight onto North Parrott Drive (US 412B) | 0.5 mi | |
| Continue slightly right onto East Main Street (US 412B) | 400 feet | |
| Turn left onto Lee Street (Hwy 23) | 900 feet | |
| Turn left onto South Harris Street (Hwy 23) | 4.4 mi | |
| Continue onto AR 23 | 18.0 mi | |
| Make a slight right onto 5th Street (AR 16) | 2.1 mi | |
| Turn left onto Hwy 23 | 200 feet | |
| Go straight onto AR 23 | 3.2 mi | |
| Continue onto Hwy 23 | 4.7 mi | |
| Continue onto AR 23 | 8.0 mi | |
| Turn right onto AR 23 | 8.7 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto I 40 | 119.7 mi | |
| Keep right onto I 40 | 124.9 mi | |
| Take the ramp towards I 55 South: Memphis | 0.5 mi | |
| Keep left onto I 55 E | 1.2 mi | |
| Continue onto I 55 | 3.5 mi | |
| Take the ramp towards I 55 South: Jackson Mississippi | 6.5 mi | |
| Continue onto I 240 E | 3.2 mi | |
| Take the ramp towards US 78: Birmingham | 700 feet | |
| Keep right towards US 78 East: Birmingham | 0.3 mi | |
| Merge left onto Lamar Avenue (US 78) | 221.0 mi | |
| Keep right towards I 65 South: Birmingham | 0.5 mi | |
| Merge left onto I 65 S | 2.0 mi | |
| Take the ramp towards Finley Boulevard | 1,000 feet | |
| Turn left onto Finley Boulevard (SR 378) | 0.7 mi | |
| Turn right onto Carraway Boulevard (US 31) | 1.5 mi | |
| Continue onto Red Mountain Expressway (US 31 S) | 2.9 mi | |
| Take the ramp onto US 280 | 108.9 mi | |
| Take the ramp on the left onto US 280 | 3.2 mi | |
| Take the ramp towards US 280: Opelika | 0.2 mi | |
| Keep right onto US 280 | 300 feet | |
| Merge left onto Columbus Parkway (US 280) | 21.1 mi | |
| Continue onto US 280 | 6.0 mi | |
| Continue onto Victory Drive (US 27) | 7.4 mi | |
| Continue onto US 27 S | 7.4 mi | |
| Continue onto US 27 | 1.5 mi | |
| Continue onto US 280 E | 18.7 mi | |
| Continue onto Wall Street (GA 520) | 16.1 mi | |
| Continue onto North Parrott Street (GA 520) | 1.0 mi | |
| Continue onto Columbus Highway (GA 520) | 7.9 mi | |
| Continue onto Martin Luther King Jr Drive (GA 45) | 0.5 mi | |
| Continue onto Roundtree Drive (GA 45) | 0.2 mi | |
| Continue onto Vine Street Northwest (GA 45) | 0.3 mi | |
| Continue onto Roundtree Drive Southwest (GA 45) | 400 feet | |
| Continue onto Rountree Drive Southwest (GA 45) | 0.5 mi | |
| Continue onto Forrester Drive Southeast (US 82) | 1.1 mi | |
| Continue onto Albany Highway (US 82) | 5.4 mi | |
| Go straight onto Highway Street (US 82) | 1.0 mi | |
| Continue onto Albany Highway (US 82) | 7.6 mi | |
| Continue onto Warrington Road (US 82) | 1.2 mi | |
| Keep right onto Liberty Expressway (US 82 E) | 8.1 mi | |
| Take exit 3 towards US 82 East: Sylvester | 0.4 mi | |
| Turn left onto Clark Avenue (US 82) | 5.4 mi | |
| Merge left onto Sylvester Highway (US 82) | 14.9 mi | |
| Continue onto US 82 | 17.0 mi | |
| Take the ramp | 0.4 mi | |
| Merge left onto I 75 S | 97.1 mi | |
| Take the ramp towards I 10: Tallahassee | 900 feet | |
| Keep left towards I 10 East: Jacksonville | 0.4 mi | |
| Merge right onto I 10 E | 4.9 mi | |
| Take the ramp towards US 41: Lake City | 0.3 mi | |
| Keep right towards US 41: Lake City | 300 feet | |
| Go straight onto US 41 | 4.2 mi | |
| Turn left onto Northwest Veterans Street | 700 feet | |
| Turn right onto North Marion Avenue (US 441) | 300 feet | |
| You have arrived at your destination |
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Eureka Springs, Arkansas - Lake City, Florida