US 54, I 55 $north
411.5 mi6 hours 43 mins
| Head southeast on North Church Street (MO 240) | 33.6 mi | |
| Continue onto I 70 E | 14.5 mi | |
| Take exit 148 towards US 54: Auxvasse | 0.2 mi | |
| Turn left onto US 54 E | 18.2 mi | |
| Turn right onto East Liberty Street (US 54) | 10.3 mi | |
| Turn left onto US 54 | 8.1 mi | |
| Turn right to stay on US 54 | 55.5 mi | |
| Turn left onto US 54 | 5.1 mi | |
| Take the ramp on the right towards I 72 East: Springfield | 0.3 mi | |
| Merge left onto I 72 E | 83.5 mi | |
| Continue onto I 55 N | 13.1 mi | |
| Keep right towards I 55 North: Chicago | 29.3 mi | |
| Keep left towards I 55 North: Chicago | 67.9 mi | |
| Continue onto I-55 N | 5.7 mi | |
| Continue onto I 55 N | 61.9 mi | |
| Take the ramp towards I 90 West: Wisconsin | 1.2 mi | |
| Keep right towards I 90 West: Wisconsin | 0.4 mi | |
| Merge left onto Dan Ryan Expressway (I 90 W) | 1.3 mi | |
| Continue onto Kennedy Expressway (I 90 W) | 0.3 mi | |
| Take the ramp towards Washington Boulevard East (100 North) | 900 feet | |
| Turn right onto West Washington Street | 0.7 mi | |
| Turn left onto North LaSalle Street | 400 feet | |
| You have arrived at your destination |
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Fayette, Missouri - Chicago, Illinois