I 40, I 55 $south
789.4 mi12 hours 24 mins
| Head south on Main Street | 0 feet | |
| Turn right onto US 42 | 1.1 mi | |
| Continue onto US 42 | 0.2 mi | |
| Turn left towards I 71 South: Louisville | 0.4 mi | |
| Merge left onto I 71 S | 6.9 mi | |
| Take the ramp towards I 71 South: Louisville | 77.3 mi | |
| Keep right towards I 65 South: Louisville | 1.0 mi | |
| Keep left at the fork | 600 feet | |
| Merge left onto I 65 S | 168.8 mi | |
| Keep left towards I 24 East: Nashville | 2.4 mi | |
| Keep right towards I 65 South: Huntisville | 2.0 mi | |
| Keep left towards I 40 West: Memphis | 0.6 mi | |
| Merge left onto I 40 | 195.9 mi | |
| Take the ramp towards I 40 West: Little Rock | 0.4 mi | |
| Make a slight left towards I 240 West: Jackson Mississippi | 0.8 mi | |
| Merge left onto I 240 W | 13.4 mi | |
| Take the ramp towards I 55 South: Jackson Mississippi | 0.3 mi | |
| Merge left onto I 240 E | 0.2 mi | |
| Continue onto I 55 S | 204.5 mi | |
| Keep left towards I 55 South: McComb | 54.0 mi | |
| Take the ramp towards US 84: South Brookhaven | 0.3 mi | |
| Keep right towards US 84: South Brookhaven | 400 feet | |
| Merge left onto US 84 | 52.8 mi | |
| Keep left onto US 84 | 3.2 mi | |
| Make a slight right onto Devereaux Drive (US 61) | 1.4 mi | |
| Continue onto St Catherine Street | 0.8 mi | |
| Make a slight right to stay on St Catherine Street | 300 feet | |
| Turn left onto North Martin Luther King Jr Street | 800 feet | |
| Turn right onto Main Street | 0.4 mi | |
| Turn right onto North Canal Street | 0 feet | |
| You have arrived at your destination |
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Florence, Kentucky - Natchez, Mississippi