I 74 $west, I 74 $west; US 421 $north
318.6 mi5 hours 29 mins
| Head northeast on Center Street | 0 feet | |
| Make a sharp left onto Oblique Street | 500 feet | |
| Turn right onto Burlington Pike (KY 18) | 0.7 mi | |
| Turn left onto Turfway Road (KY 1017) | 600 feet | |
| Take the ramp on the right towards I 71 North: Cincinnati | 0.2 mi | |
| Merge left onto I 71 N | 1.5 mi | |
| Take exit 185 towards I 275: Airport | 0.3 mi | |
| Keep left towards I 275 West | 0.8 mi | |
| Merge left onto I 275 W | 13.7 mi | |
| Continue onto I 275 N | 1.0 mi | |
| Take exit 16 towards US 50: Greendale | 1.2 mi | |
| Keep left at the fork | 300 feet | |
| Continue onto Belleview Drive (SR 1) | 0.4 mi | |
| Turn right onto SR 1 | 400 feet | |
| Turn left onto SR 1 | 14.3 mi | |
| Take the ramp on the left towards I 74 West: Indianapolis | 900 feet | |
| Merge left onto I 74 W | 69.4 mi | |
| Continue towards Southeastern Avenue | 1.2 mi | |
| Continue onto Southeastern Avenue | 0.8 mi | |
| Make a slight left onto East Raymond Street | 3.4 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto I 65 N | 0.7 mi | |
| Take exit 110B on the left towards I 70 West: Saint Louis | 0.6 mi | |
| Merge left onto I 70 | 3.7 mi | |
| Take the ramp towards Holt Road | 0.3 mi | |
| Turn right onto South Holt Road | 0.7 mi | |
| Turn left onto Rockville Road | 2.1 mi | |
| Take the ramp on the right | 0.5 mi | |
| Merge left onto I 74 W | 1.8 mi | |
| Continue onto I 74 | 0.2 mi | |
| Continue onto I 74:I 465 W | 400 feet | |
| Keep right onto I 74 W | 114.7 mi | |
| Take exit 179A towards I 57 South: Memphis | 0.3 mi | |
| Merge left onto I 57 S | 1.9 mi | |
| Take the ramp towards I 72 West: Springfield | 0.5 mi | |
| Merge left onto I 72 W | 29.5 mi | |
| Continue onto I-72 W | 11.0 mi | |
| Continue onto I 72 W | 1,000 feet | |
| Continue onto I-72 | 6.2 mi | |
| Continue onto I-72 W | 0.6 mi | |
| Take the ramp towards I 72 West | 3.2 mi | |
| Continue onto I 72 W | 27.5 mi | |
| Continue onto East Clear Lake Avenue (IL 97 N) | 2.3 mi | |
| Merge right onto East Jefferson Street (IL 29) | 0.3 mi | |
| Turn left onto North 9th Street (I 55 Business) | 500 feet | |
| You have arrived at your destination |
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Florence, Kentucky - Springfield, Illinois