How to get from Florence, South Carolina to Roanoke, Virginia

Discover, print or download the driving directions for the best route to go from Florence, South Carolina to Roanoke, Virginia.

Enlarge the route map Florence, South Carolina - Roanoke, Virginia

Driving directions from Florence, South Carolina to Roanoke, Virginia

I 73 $north; I 74 $west; US 220 $north, Virgil H Goode Highway

246.1 mi4 hours 33 mins

Head east on West Palmetto Street (US 76) 100 feet
Turn left onto South Irby Street (US 52) 0.8 mi
Turn left onto West Lucas Street (US 52) 4.0 mi
Continue onto South Main Street (US 52) 3.4 mi
Continue straight to stay on South Main Street (US 52 Business) 1.6 mi
Turn right onto Pearl Street (SC 34) 200 feet
Turn left onto Exchange Street (SC 34) 200 feet
Turn right onto Cashua Street (SC 34) 0.9 mi
Turn left onto Society Hill Road 13.4 mi
Keep right onto Church Street 1.0 mi
Make a slight right onto Cheraw Highway (US 52) 13.5 mi
Merge left onto Market Street (US 1) 0.9 mi
Turn left onto 2nd Street (US 1) 0.4 mi
Turn right onto US 1 1.9 mi
Turn left onto US 1 17.3 mi
Keep left onto US 220 80.4 mi
Take the ramp towards I 40 700 feet
Keep left towards I 40 West 0.7 mi
Merge left onto I 40 7.8 mi
Take the ramp towards NC 68: High Point 0.2 mi
Keep left at the fork 400 feet
Keep right at the fork 300 feet
Merge left onto NC 68 N 3.6 mi
Take the ramp towards I 73 North: Martinsville 0.5 mi
Merge left onto I 73 N 12.2 mi
Continue onto US 220 N 24.3 mi
Turn left towards US 58 West 0.3 mi
Merge left onto William F Stone Highway (US 58) 16.8 mi
Continue onto Virgil H Goode Highway (US 220 N) 39.0 mi
Take the ramp towards US 221: Vinton 700 feet
Turn left onto Elm Avenue Southeast (VA 24) 0.3 mi
Turn right onto South Jefferson Street (VA 116) 0.3 mi
You have arrived at your destination

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Florence, South Carolina - Roanoke, Virginia

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