I 64 $west, I 70 $west; US 40 $west
545.0 mi8 hours 29 mins
| Head south on North Main Street (US 31W) | 0.3 mi | |
| Turn left onto KY 100 | 3.3 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto I 65 N | 13.6 mi | |
| Take exit 20A-B towards I 165: Owensboro | 0.3 mi | |
| Keep left towards I 165: Owensboro | 0.4 mi | |
| Keep right towards i 165 North: Owensboro | 0.3 mi | |
| Merge left onto I 165 N | 70.1 mi | |
| Keep right towards US 60 East: Hawesville | 0.3 mi | |
| Merge left onto Wendell Ford Expressway (US 60 E) | 0.8 mi | |
| Take exit 18 towards KY 54 | 0.3 mi | |
| Turn left onto Leitchfield Road (KY 54) | 300 feet | |
| Continue onto East Parrish Avenue (KY 54) | 2.3 mi | |
| Turn right onto J R Miller Boulevard (KY 2262) | 0.6 mi | |
| Continue onto Glover Cary Bridge (KY 2262) | 1.0 mi | |
| Continue onto SR 161 | 7.9 mi | |
| Turn left onto SR 66 | 21.2 mi | |
| Take the ramp | 0.6 mi | |
| Merge left onto Robert D. Orr Highway (I 69 N) | 13.4 mi | |
| Take exit 21B towards I 64 West: Saint Louis | 0.3 mi | |
| Merge left onto I 64 W | 81.5 mi | |
| Keep right towards I 57 North | 4.6 mi | |
| Take the ramp on the left towards I 64 West: Saint Louis | 70.7 mi | |
| Take the ramp towards I 70 West: Kansas City | 0.7 mi | |
| Merge right onto I 70 W | 248.8 mi | |
| Keep right towards I 70 West: Saint Joseph | 0.2 mi | |
| Take exit 2K towards Harrison Street | 400 feet | |
| Continue onto Harrison Street | 0.3 mi | |
| Turn left onto East 9th Street | 0.6 mi | |
| Turn left onto South Main Street | 100 feet | |
| You have arrived at your destination |
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Franklin, Kentucky - Kansas City, Missouri