I 40, I 81 $north
1,101.0 mi17 hours 25 mins
| Head northeast on Main Street (US 31) | 500 feet | |
| Enter Public Square and take the 2nd exit onto East Main Street | 200 feet | |
| Exit the roundabout onto East Main Street | 900 feet | |
| Continue slightly left onto Franklin Road (US 31) | 6.1 mi | |
| Turn right onto Concord Road (TN 253) | 0.8 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto I 65 N | 8.1 mi | |
| Take the ramp towards I 440: Memphis | 0.2 mi | |
| Keep right towards Knoxville | 0.4 mi | |
| Merge left onto Four-Forty Parkway (I 440 E) | 2.0 mi | |
| Keep left towards I 24 West: Nashville | 0.8 mi | |
| Merge left onto I 24 W | 0.3 mi | |
| Keep right towards I 40 East: Knoxville | 0.3 mi | |
| Merge left onto I 40 | 207.7 mi | |
| Keep left towards I 81 North: Bristol | 526.2 mi | |
| Keep right towards I 78 East: Allentown | 50.9 mi | |
| Keep left towards I 78 East: New Jersey | 74.5 mi | |
| Keep left onto Interstate 78 Express (I 78 E) | 10.2 mi | |
| Take the ramp | 300 feet | |
| Keep left at the fork | 1.4 mi | |
| Keep right at the fork | 0.9 mi | |
| Merge left onto New Jersey Turnpike (I 95 N) | 10.3 mi | |
| Take the ramp towards US 46: The Ridgefields | 800 feet | |
| Keep right towards US 46 East: Ridgefield | 0.3 mi | |
| Merge right onto US 46 | 2.7 mi | |
| Take the ramp on the left | 600 feet | |
| Merge left onto I 95 | 1.7 mi | |
| Continue onto Trans-Manhattan Expressway (I 95 N) | 0.7 mi | |
| Continue onto Cross Bronx Expressway (I 95 N) | 4.7 mi | |
| Keep left onto I 95 N | 2.9 mi | |
| Take exit 9 towards Hutchinson Parkway North | 400 feet | |
| Keep left towards Hutchinson River Parkway North | 0.2 mi | |
| Merge left onto Hutchinson River Parkway (HRP N) | 1.5 mi | |
| Take exit 6 towards I 95 North: New Haven | 0.3 mi | |
| Merge left onto New England Thruway (I 95 N) | 3.7 mi | |
| Keep right onto New England Thruway (I 95 N) | 100 feet | |
| Merge right onto New England Thruway (I 95 N) | 55.5 mi | |
| Take the ramp towards I 91 North: Hartford | 0.6 mi | |
| Continue onto I 91 | 36.4 mi | |
| Take the ramp towards US 5 North: East Hartford | 0.4 mi | |
| Merge left onto Charter Oak Bridge (US 5) | 0.4 mi | |
| Continue onto Wilbur Cross Highway (CT 15 N) | 42.1 mi | |
| Keep right towards I 90 East: New Hampshire | 0.4 mi | |
| Merge left onto Massachusetts Turnpike (I 90 E) | 11.2 mi | |
| Take exit 10 towards I 395: Auburn | 0.3 mi | |
| Keep left at the fork | 0.7 mi | |
| Continue onto I 290 E | 7.5 mi | |
| Take exit 19 towards I 190 North: Holden | 800 feet | |
| Keep left towards I 190 North: Holden | 0.4 mi | |
| Continue onto I 190 N | 18.1 mi | |
| Keep right towards MA 2 East: Boston | 0.6 mi | |
| Merge left onto Leominster Connector | 900 feet | |
| Merge left onto Concord Turnpike (MA 2) | 2.6 mi | |
| Take exit 36 towards Shirley | 800 feet | |
| Keep right at the fork | 200 feet | |
| Go straight onto Shirley Road | 0.9 mi | |
| Continue onto Lancaster Road | 1.2 mi | |
| Continue onto Main Street | 1,000 feet | |
| You have arrived at your destination |
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Franklin, Tennessee - Shirley, Massachusetts