How to get from Fort Myers, Florida to Key West, Florida

Discover, print or download the driving directions for the best route to go from Fort Myers, Florida to Key West, Florida.

Enlarge the route map Fort Myers, Florida - Key West, Florida

Driving directions from Fort Myers, Florida to Key West, Florida

Alligator Alley, Overseas Highway

298.6 mi5 hours 20 mins

Head east on Dr Martin Luther King Boulevard (FL 82) 0.5 mi
Continue onto Doctor Martin Luther King Boulevard (FL 82) 1.0 mi
Continue onto Dr Martin Luther King Boulevard (FL 82) 0.7 mi
Continue onto Doctor Martin Luther King Boulevard (FL 82) 1.2 mi
Continue onto Dr Martin Luther King Boulevard (FL 82) 0.7 mi
Take the ramp on the right 0.4 mi
Merge left onto I 75 S 112.7 mi
Take the ramp towards US 27: Miami 0.2 mi
Keep right towards US 27 South: Miami 0.5 mi
Merge left onto US 27 17.8 mi
Take the ramp on the left towards Florida's Turnpike Toll South 0.3 mi
Merge left onto Homestead Extension of Florida's Turnpike 35.4 mi
Merge left onto Dixie Highway (US 1) 19.3 mi
Continue onto Overseas Highway (US 1) 104.0 mi
Keep right onto US 1 2.9 mi
Turn right onto White Street 0.3 mi
Turn left onto Southard Street 0.5 mi
Turn left onto Simonton Street 400 feet
Turn right onto Angela Street 100 feet
You have arrived at your destination

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Fort Myers, Florida - Key West, Florida

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