I 59 $north, I 81 $north
857.5 mi13 hours
| Head east on West Main Street (MS 178) | 0.4 mi | |
| Turn right onto South Adams Street | 2.2 mi | |
| Take the ramp on the left | 24.5 mi | |
| Continue onto I 22 E | 84.0 mi | |
| Keep right towards I 65 South: Birmingham | 0.5 mi | |
| Merge left onto I 65 S | 2.0 mi | |
| Take the ramp towards Finley Boulevard | 1,000 feet | |
| Turn left onto Finley Boulevard (SR 378) | 0.7 mi | |
| Turn right onto Carraway Boulevard (US 31) | 1.4 mi | |
| Turn right onto Richard Arrington Jr Boulevard North | 500 feet | |
| Take the ramp on the right towards I 20 East: Atlanta | 0.7 mi | |
| Merge left onto I 20 | 3.0 mi | |
| Keep left towards I 59 North: Gadsden | 130.7 mi | |
| Keep right towards I 24 East: Chattanooga | 0.7 mi | |
| Merge left onto I 24 E | 16.6 mi | |
| Keep left towards Knoxville | 0.6 mi | |
| Merge right onto I 75 N | 72.4 mi | |
| Keep right onto I 75 N | 63.8 mi | |
| Keep left towards I 81 North: Bristol | 375.8 mi | |
| Take the ramp towards I 66 East: Front Royal | 0.4 mi | |
| Continue onto I 66 E | 74.2 mi | |
| Keep left towards I 66 East: Washington | 1,000 feet | |
| Continue onto Theodore Roosevelt Memorial Bridge (I 66 E) | 0.6 mi | |
| Take the ramp towards Independence Avenue | 900 feet | |
| Merge left onto Potomac Freeway | 300 feet | |
| Merge right onto Rock Creek and Potomac Parkway Northwest | 200 feet | |
| Merge left onto Ohio Drive Southwest | 0.2 mi | |
| Continue onto Independence Avenue Southwest | 0.8 mi | |
| Continue straight to stay on Independence Avenue Southwest | 900 feet | |
| Turn left onto Raoul Wallenberg Place Southwest | 500 feet | |
| Turn right onto Jefferson Drive Southwest | 300 feet | |
| Turn left onto 14th Street Southwest (US 1 N) | 600 feet | |
| You have arrived at your destination |
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Fulton, Mississippi - Washington, District of Columbia