US Highway 61, US 14; US 61
129.5 mi2 hours 41 mins
| Head southwest on North Main Street | 200 feet | |
| Turn right onto Franklin Street | 1.3 mi | |
| Turn right onto US 20 | 1.8 mi | |
| Turn right onto IL 84 | 4.1 mi | |
| Continue onto State Highway 80 (WI 80) | 1.9 mi | |
| Continue onto North Percival Street (WI 11) | 1.0 mi | |
| Continue onto State Highway 11 (WI 11) | 1.9 mi | |
| Continue onto State Highway 80 (WI 80) | 2.0 mi | |
| Continue onto South Main Street (WI 80) | 900 feet | |
| Continue onto State Highway 80 (WI 80) | 9.5 mi | |
| Continue onto South Water Street (WI 80) | 0.6 mi | |
| Turn left onto East Furnace Street | 0.3 mi | |
| Turn right onto North Chestnut Street (WI 81) | 600 feet | |
| Turn left onto West Adams Street (WI 81) | 700 feet | |
| Make a slight right onto Lancaster Street (WI 81) | 0.7 mi | |
| Continue onto State Highway 81 (WI 81) | 9.7 mi | |
| Continue onto Kingsford Road (WI 81) | 2.3 mi | |
| Continue onto US Highway 61 (US 61) | 0.5 mi | |
| Turn right onto State Highway 129 (WI 129) | 2.7 mi | |
| Turn right onto Lincoln Avenue (US 61) | 9.7 mi | |
| Continue onto Elm Street (US 61) | 12.2 mi | |
| Turn right onto US Highway 61 (US 61) | 21.4 mi | |
| Continue onto Soldiers Grove Road (US 61) | 1.6 mi | |
| Turn left onto West Kickapoo Street (US 14) | 0.3 mi | |
| Continue onto US Highway 14 (US 14) | 7.3 mi | |
| Continue onto South Main Street (US 14) | 20.8 mi | |
| Continue onto US 14 | 13.2 mi | |
| Continue onto South Avenue (US 14) | 1.5 mi | |
| Continue onto 4th Street South (US 14) | 0.7 mi | |
| Turn left onto Cass Street (US 14) | 0 feet | |
| You have arrived at your destination |
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Galena, Illinois - La Crosse, Wisconsin