US 521, SC 151
171.6 mi3 hours 30 mins
| Head northwest on Highmarket Street | 200 feet | |
| Turn right onto Broad Street | 0.2 mi | |
| Turn left onto Church Street (US 17) | 0.8 mi | |
| Merge left onto Highmarket Street (US 17 Alternate) | 9.4 mi | |
| Continue onto Georgetown Highway (US 521) | 6.2 mi | |
| Continue straight to stay on Georgetown Highway (US 521 Business) | 1.7 mi | |
| Continue onto East Main Street (US 521 Business) | 19.1 mi | |
| Turn right onto Martin Luther King Jr Avenue (SC 377) | 5.8 mi | |
| Turn left onto Nelson Boulevard (SC 527) | 0.8 mi | |
| Continue onto South Longstreet Street (SC 527) | 1.9 mi | |
| Continue onto North Williamsburg County Highway (US 52) | 11.1 mi | |
| Continue onto South Ron McNair Boulevard (US 52) | 15.2 mi | |
| Continue onto South Irby Street (US 52) | 7.0 mi | |
| Turn right onto Freedom Boulevard (US 301) | 1.3 mi | |
| Turn left onto South Church Street | 2.9 mi | |
| Continue onto East Lucas Street | 4.6 mi | |
| Continue onto South Main Street (US 52) | 3.4 mi | |
| Continue left onto North Governor Williams Highway (US 52) | 2.1 mi | |
| Take the ramp | 1,000 feet | |
| Turn left onto Harry Byrd Highway (SC 34) | 4.8 mi | |
| Continue onto East Bobo Newsome Highway (SC 34) | 15.3 mi | |
| Continue onto State Highway 151 (SC 151) | 4.9 mi | |
| Continue onto Pine Avenue (SC 151) | 18.2 mi | |
| Continue onto State Highway 151 (SC 151) | 7.1 mi | |
| Continue onto Van Lingle Mungo Boulevard (SC 151) | 1.2 mi | |
| Continue onto US 601 | 14.7 mi | |
| Make a slight left onto East Roosevelt Boulevard (US 74) | 4.8 mi | |
| Continue onto Independence Boulevard (US 74) | 5.8 mi | |
| Turn left onto Unionville Indian Trail Road West | 0.9 mi | |
| Turn left onto North Indian Trail Road | 600 feet | |
| Turn right onto Navajo Trail | 200 feet | |
| You have arrived at your destination |
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Georgetown, South Carolina - Indian Trail, North Carolina