I 20; I 59 $south, I 59 $south
249.0 mi4 hours 4 mins
| Head south on Tuscaloosa Street (SR 69) | 0.3 mi | |
| Turn right onto State Street (SR 14) | 0.7 mi | |
| Turn right onto Hobson Street (SR 14) | 12.8 mi | |
| Make a slight left onto SR 14 | 7.8 mi | |
| Turn right onto Morrow Avenue (US 11) | 300 feet | |
| Turn left onto Tuscaloosa Street (US 11) | 1,000 feet | |
| Continue onto Main Street (SR 14) | 700 feet | |
| Turn right onto Eutaw Avenue (SR 14) | 300 feet | |
| Turn left onto Mesopotamia Street (AL 14) | 2.7 mi | |
| Take the ramp on the left | 0.2 mi | |
| Merge left onto I 20 | 62.1 mi | |
| Continue onto I 20 | 1.8 mi | |
| Keep left towards I 59 South: Laurel | 53.3 mi | |
| Continue onto Lance Corporal Roy M Wheat Memorial Highway (I 59 S) | 35.6 mi | |
| Take the ramp towards US 98 East: Lucedale | 3.2 mi | |
| Take the ramp towards US 49: Wiggins | 0.3 mi | |
| Keep left towards Multi Purpose Center | 800 feet | |
| Turn right onto US 49 | 42.0 mi | |
| Take the ramp | 0.8 mi | |
| Continue onto MS 67 S | 20.5 mi | |
| Continue onto I 110 S | 3.7 mi | |
| Keep left towards US 90: Gulfport | 0.5 mi | |
| Go straight onto Beach Boulevard (US 90) | 500 feet | |
| You have arrived at your destination |
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Greensboro, Alabama - Biloxi, Mississippi