US 278; MS 6, MS 7
114.2 mi2 hours 1 min
| Head northwest on Bryson Street | 500 feet | |
| Continue onto North Main Street | 0.8 mi | |
| Take the ramp on the left | 0.4 mi | |
| Merge left onto US 45 | 10.5 mi | |
| Take the ramp towards US 78:west: Memphis | 0.5 mi | |
| Merge left onto I 22 W | 8.9 mi | |
| Take the ramp towards MS 9 South: Sherman | 0.3 mi | |
| Keep left at the fork | 200 feet | |
| Merge right onto MS 9 | 9.8 mi | |
| Take the ramp | 0.3 mi | |
| Merge left onto Pontotoc Parkway West (US 278) | 29.8 mi | |
| Continue onto MS 6 | 0.5 mi | |
| Continue onto US 278 W | 1.0 mi | |
| Take the ramp towards MS 7: Holly Springs | 1,000 feet | |
| Keep left at the fork | 200 feet | |
| Merge left onto MS 7 | 6.4 mi | |
| Continue straight to stay on MS 7 | 36.6 mi | |
| Take the ramp on the left onto MS 7 S | 4.4 mi | |
| Continue onto I 55 S | 0.6 mi | |
| Take the ramp onto MS 7 S | 0.2 mi | |
| Keep left at the fork | 300 feet | |
| Go straight onto Sunset Drive (MS 7) | 2.7 mi | |
| Make a slight left | 300 feet | |
| Turn right onto Sunset Drive | 500 feet | |
| Turn left onto South Mound Street | 200 feet | |
| You have arrived at your destination, on the left |
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Guntown, Mississippi - Granada, Mississippi