I 75 $south, I 64 $east
139.9 mi2 hours 18 mins
| Head east on High Street (SR 129) | 1.5 mi | |
| Continue onto Butler County Veterans Highway (SR 129 E) | 1.4 mi | |
| Take exit 18 towards SR 4 Bypass: Middletown | 0.3 mi | |
| Turn right onto Bypass 4 (SR 4 Bypass) | 4.2 mi | |
| Take the ramp | 500 feet | |
| Turn left | 200 feet | |
| Turn left onto Dixie Highway (SR 4) | 2.1 mi | |
| Continue onto Springfield Pike (SR 4) | 900 feet | |
| Take the ramp on the right towards I 275 | 900 feet | |
| Keep left towards I 275 East: Dayton | 0.5 mi | |
| Merge left onto Cincinnati By-Pass (I 275 E) | 1.9 mi | |
| Take exit 43A towards I 75 South: Cincinnati | 0.3 mi | |
| Continue towards I 75 South: Cincinnati | 0.6 mi | |
| Merge left onto Mill Creek Expressway (I 75 S) | 16.0 mi | |
| Continue onto Brent Spence Bridge (I 71 S) | 80.5 mi | |
| Take exit 111 on the left towards I 64 East: Winchester | 16.6 mi | |
| Keep left onto I 64 E | 11.9 mi | |
| Take exit 110 towards US 460: Flemingsburg | 0.3 mi | |
| Turn right onto Maysville Road (US 460) | 1.4 mi | |
| You have arrived at your destination |
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Hamilton, Ohio - Mt Sterling, Kentucky