I 81 $south, Dwight D Eisenhower Highway
108.6 mi1 hour 48 mins
| Head northwest on North 2nd Street | 400 feet | |
| Turn left onto Walnut Street | 500 feet | |
| Turn left onto North Front Street | 0.5 mi | |
| Keep left onto I 83 | 0.2 mi | |
| Keep left at the fork | 0.3 mi | |
| Merge left onto I 83 S | 1.0 mi | |
| Keep left towards PA 581 West: Camp Hill | 7.4 mi | |
| Keep left towards I 81 South: Carlisle | 0.6 mi | |
| Merge right onto American Legion Memorial Highway (I 81 S) | 66.9 mi | |
| Take the ramp towards I 70 East & West: Hancock | 0.2 mi | |
| Keep right towards I 70 West: Hancock | 0.4 mi | |
| Merge left onto Dwight D Eisenhower Highway (I 70) | 16.3 mi | |
| Continue onto I 70, US 40 (Dwight D Eisenhower Highway) (I 70 W) | 3.1 mi | |
| Continue onto Dwight D Eisenhower Highway (I 70) | 4.5 mi | |
| Take the ramp on the left towards US 522 South: Hancock | 0.6 mi | |
| Merge left onto Warfordsburg Road (US 522 S) | 0.6 mi | |
| Continue onto Hancock Road (US 522) | 4.5 mi | |
| Continue onto North Washington Street (US 522) | 0.9 mi | |
| Turn left onto Martinsburg Rd (WV 9) | 400 feet | |
| Turn right onto Martinsburg Road (WV 9) | 900 feet | |
| Turn right onto Ewing Street | 0 feet | |
| You have arrived at your destination |
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Harrisburg, Pennsylvania - Berkeley Springs, West Virginia