Pennsylvania Turnpike, Indiana Toll Road
665.8 mi10 hours 3 mins
| Head northwest on North 2nd Street | 400 feet | |
| Turn left onto Walnut Street | 500 feet | |
| Turn left onto North Front Street | 0.5 mi | |
| Keep left onto I 83 | 0.2 mi | |
| Keep left at the fork | 0.3 mi | |
| Merge left onto I 83 S | 1.0 mi | |
| Keep left towards PA 581 West: Camp Hill | 2.0 mi | |
| Take the ramp towards US 15 South: Gettysburg | 0.2 mi | |
| Keep left towards US 15 South: Gettysburg | 0.4 mi | |
| Continue slightly right onto US 15 S | 3.2 mi | |
| Take the ramp towards I 76: Philadelphia | 0.4 mi | |
| Keep right towards I 76 West: Pittsburgh | 0.2 mi | |
| Merge left onto Pennsylvania Turnpike (I 76 W) | 205.6 mi | |
| Keep right onto Pennsylvania Turnpike (I 76 W) | 31.2 mi | |
| Continue onto Ohio Turnpike (I 76 W) | 6.9 mi | |
| Keep left onto Ohio Turnpike (I 76 W) | 72.5 mi | |
| Go straight towards I 71 North: Cleveland | 0.6 mi | |
| Merge left onto I 71 N | 5.1 mi | |
| Take the ramp towards I 480: Airport - Toledo | 0.4 mi | |
| Keep left at the fork | 0.6 mi | |
| Merge left onto Outerbelt South Freeway (I 480 W) | 9.4 mi | |
| Keep right onto I 480 W | 1.2 mi | |
| Merge left onto Ohio Turnpike (I 80 W) | 151.1 mi | |
| Continue onto Indiana Toll Road (I 80) | 156.6 mi | |
| Continue onto Chicago Skyway (I 90 W) | 7.2 mi | |
| Keep left towards I 90 Express | 0.4 mi | |
| Merge left onto Dan Ryan Expressway (I 90) | 7.2 mi | |
| Continue onto Kennedy Expressway (I 90 W) | 0.3 mi | |
| Take the ramp towards Washington Boulevard East (100 North) | 900 feet | |
| Turn right onto West Washington Street | 0.7 mi | |
| Turn left onto North LaSalle Street | 400 feet | |
| You have arrived at your destination |
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Harrisburg, Pennsylvania - Chicago, Illinois