US 65, I 22 $east; US 78 $east
390.7 mi6 hours 48 mins
| Head east on West Central Avenue (AR 7) | 800 feet | |
| Turn right onto South Main Street (US 65B) | 1.6 mi | |
| Continue onto US 62 | 65.7 mi | |
| Continue onto US 65 | 38.1 mi | |
| Take the ramp on the left onto US 65 S | 29.6 mi | |
| Keep right onto I 40 | 124.9 mi | |
| Take the ramp towards I 55 South: Memphis | 0.5 mi | |
| Keep left onto I 55 E | 1.2 mi | |
| Continue onto I 55 | 3.5 mi | |
| Take the ramp towards I 55 South: Jackson Mississippi | 6.5 mi | |
| Continue onto I 240 E | 3.2 mi | |
| Take the ramp towards US 78: Birmingham | 700 feet | |
| Keep right towards US 78 East: Birmingham | 0.3 mi | |
| Merge left onto Lamar Avenue (US 78) | 112.2 mi | |
| Take the ramp towards Fulton | 0.3 mi | |
| Go straight onto South Adams Street | 2.2 mi | |
| Turn left onto East Main Street (MS 178) | 0.4 mi | |
| You have arrived at your destination |
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Harrison, Arkansas - Fulton, Mississippi