I 59 $north, I 20; I 59 $north
347.0 mi5 hours 18 mins
| Head northwest on North Main Street | 1.3 mi | |
| Turn left onto Old Highway 42 | 0.2 mi | |
| Turn right onto Glendale Avenue | 1.3 mi | |
| Keep right onto Monroe Road | 1,000 feet | |
| Turn left onto Evelyn Gandy Parkway (MS 42) | 2.0 mi | |
| Take the ramp towards North I 59 | 900 feet | |
| Merge left onto Lance Corporal Roy M Wheat Memorial Highway (I 59 N) | 25.2 mi | |
| Continue towards North I 59: Meridian | 0.5 mi | |
| Continue onto Lance Corporal Roy M Wheat Memorial Highway (I 59 N) | 52.2 mi | |
| Keep right towards I 59 North: Meridian | 129.7 mi | |
| Take the ramp towards I 459 North: Gadsden | 0.5 mi | |
| Continue onto John M. Harbert III Freeway (I 459 N) | 8.7 mi | |
| Continue onto John M Harbert III Freeway (I 459 N) | 2.0 mi | |
| Continue onto John M. Harbert III Freeway (I 459 N) | 22.0 mi | |
| Keep right towards 59: Gadsden | 0.3 mi | |
| Continue towards I-59 North: Gadsden | 900 feet | |
| Merge left onto I 59 N | 93.6 mi | |
| Take exit 231 towards 117: Hammondville | 900 feet | |
| Turn right onto SR 117 | 1.2 mi | |
| Turn right onto US 11 | 700 feet | |
| Turn left onto SR 117 | 5.4 mi | |
| You have arrived at your destination |
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Hattiesburg, Mississippi - Mentone, Alabama