I 80, I 99 $south; US 220 $south
336.5 mi5 hours 38 mins
| Head southeast on Main Avenue (US 6 E) | 900 feet | |
| Continue onto Spring Street (US 6 E) | 400 feet | |
| Continue onto Bellemonte Avenue (US 6 E) | 0.8 mi | |
| Continue onto Welwood Avenue (US 6 E) | 0.6 mi | |
| Continue onto Lake Wallenpaupack Road (US 6 E) | 1.4 mi | |
| Turn right to stay on Lake Wallenpaupack Road (PA 507) | 1.5 mi | |
| Turn left onto PA 390 | 3.2 mi | |
| Turn right onto Fairview Lake Road (PA 390) | 1.9 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge right onto I 84 W | 25.7 mi | |
| Keep left towards I 81 South: Wilkes-Barre | 1.2 mi | |
| Merge left onto American Legion Memorial Highway (I 81 S) | 35.0 mi | |
| Take exit 151B towards I-80 West: Bloomsburg | 0.7 mi | |
| Merge left onto I 80 | 98.4 mi | |
| Take the ramp towards I-99 south : Bellefonte | 0.3 mi | |
| Turn left onto Jacksonville Road (US 220) | 1.0 mi | |
| Continue onto I 99 S | 23.2 mi | |
| Keep left onto I 99 S | 61.7 mi | |
| Take the ramp towards Pittsburgh | 0.9 mi | |
| Turn right onto North Richard Street (US 220 Business) | 0.3 mi | |
| Take the ramp towards I 70: Pittsburgh | 1,000 feet | |
| Keep right towards I 76 West: Pittsburgh | 0.2 mi | |
| Merge left onto Pennsylvania Turnpike (I 70 W) | 55.1 mi | |
| Take the ramp towards PA 31: Ligonier | 0.3 mi | |
| Turn left onto PA 31 | 2.2 mi | |
| Turn right onto PA 381 | 9.6 mi | |
| Turn left onto Mill Run Road (PA 381) | 0.7 mi | |
| Keep left onto Mill Run Road (PA 381) | 10.0 mi | |
| Turn left onto Sheridan Street | 300 feet | |
| Turn right onto Sherman Street | 100 feet | |
| You have arrived at your destination |
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Hawley, Pennsylvania - Ohiopyle, Pennsylvania