I 95 $south, I 75 $south
1,187.3 mi18 hours 23 mins
| Head east on Blair Street (US 22 E) | 500 feet | |
| Turn right onto Penn Street (PA 36 S) | 400 feet | |
| Continue onto Charger Highway (PA 36 S) | 5.0 mi | |
| Turn right onto Woodbury Pike (PA 164 W) | 0.2 mi | |
| Continue straight | 800 feet | |
| Keep left at the fork | 0.8 mi | |
| Merge left onto I 99 S | 22.3 mi | |
| Take the ramp towards Pittsburgh | 0.9 mi | |
| Turn right onto North Richard Street (US 220 Business) | 0.3 mi | |
| Take the ramp towards I 70: Pittsburgh | 1,000 feet | |
| Keep left towards I 76 East: Harrisburg | 0.3 mi | |
| Merge left onto Pennsylvania Turnpike (I 70) | 15.6 mi | |
| Take the ramp towards US 30: Breezewood | 1.9 mi | |
| Keep left towards US 30 West: Breezewood | 0.7 mi | |
| Turn left towards I 70 East: Baltimore | 75.9 mi | |
| Take the ramp towards Washington | 0.4 mi | |
| Continue onto Eisenhower Memorial Highway (I 270 N) | 22.9 mi | |
| Keep right onto I 270 S | 0.3 mi | |
| Continue onto I 270 N | 6.4 mi | |
| Keep right towards I 270 Spur: Washington | 2.0 mi | |
| Merge right onto Capital Beltway (I 495 W) | 1.2 mi | |
| Keep left onto Capital Beltway (I 495 W) | 4.7 mi | |
| Keep right onto Capital Beltway (I 495 S) | 11.3 mi | |
| Take the ramp towards I 95 South: Richmond | 0.5 mi | |
| Keep left at the fork | 0.3 mi | |
| Keep left towards I 95 South: Richmond | 0.4 mi | |
| Merge left onto Henry G. Shirley Memorial Highway (I 395 S) | 58.7 mi | |
| Continue onto I 95 S | 25.7 mi | |
| Take the ramp on the left towards I 295 South: Rocky Mount NC | 1.8 mi | |
| Merge right onto I 295 | 42.4 mi | |
| Merge right towards I 95 South: Emporia | 559.1 mi | |
| Take the ramp towards I 295 West Beltway: Orange Park | 0.6 mi | |
| Continue onto I 295 S | 13.8 mi | |
| Take the ramp towards I-10 West | 0.4 mi | |
| Merge left onto I 10 W | 12.6 mi | |
| Take the ramp towards US 301: Baldwin | 0.2 mi | |
| Keep right at the fork | 600 feet | |
| Merge left onto US 301 | 36.7 mi | |
| Keep left onto Sid Martin Highway (US 301) | 39.1 mi | |
| Turn right onto Northwest 70th Street (FL 326) | 1.7 mi | |
| Continue onto NW 77th Street (FL 326) | 0.9 mi | |
| Continue onto CR 326 | 0.2 mi | |
| Take the ramp on the left | 0 feet | |
| Turn left onto CR 326 | 1,000 feet | |
| Take the ramp | 0.3 mi | |
| Merge left onto I 75 S | 29.1 mi | |
| Keep right towards I 75 South: Tampa | 53.5 mi | |
| Keep left towards South I 75: Naples | 16.2 mi | |
| Continue onto I 75 S | 58.3 mi | |
| Keep left onto I 75 S | 42.2 mi | |
| Take the ramp towards Tuckers Grade | 0.3 mi | |
| Keep left at the fork | 300 feet | |
| Turn right onto Tuckers Grade (CR 762) | 1.0 mi | |
| Turn left onto Tamiami Trail (US 41) | 11.4 mi | |
| Make a slight left to stay on North Tamiami Trail (US 41 Business) | 4.2 mi | |
| Continue onto Edison Bridge South (US 41 Business) | 1.0 mi | |
| Continue onto Fowler Street (US 41 Business) | 800 feet | |
| Turn right onto Second Street | 0.3 mi | |
| Turn left onto Hendry Street | 700 feet | |
| Turn right onto Dr Martin Luther King Boulevard (FL 82) | 100 feet | |
| You have arrived at your destination |
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Hollidaysburg, Pennsylvania - Fort Myers, Florida