I 22 $west; US 78 $west, I 40
1,802.3 mi1 day 2 hours 34 mins
| Head southwest on Kelly Creek Road | 3.1 mi | |
| Continue onto Kelley Creek Road | 0.4 mi | |
| Take the ramp on the right | 900 feet | |
| Merge left onto I 20 | 20.2 mi | |
| Take the ramp towards 31st Street North | 900 feet | |
| Turn right onto 31st Street North | 400 feet | |
| Turn left onto 12th Avenue North | 0.5 mi | |
| Turn right onto Carraway Boulevard (US 31) | 1.2 mi | |
| Turn left onto Finley Boulevard (SR 378) | 0.6 mi | |
| Turn right onto 19th Street North | 0 feet | |
| Take the ramp | 800 feet | |
| Merge left onto I 65 N | 1.7 mi | |
| Take the ramp towards I 22 West: Memphis | 1.2 mi | |
| Continue onto I 22 W | 220.7 mi | |
| Take the ramp towards I 240: Nashville | 600 feet | |
| Keep left towards I 240 West: Saint Louis | 0.7 mi | |
| Merge left onto I 240 W | 4.1 mi | |
| Continue onto I 55 N | 5.5 mi | |
| Take the ramp towards I 55 North: Saint Louis | 7.9 mi | |
| Keep left onto I 40 | 442.7 mi | |
| Keep left onto Tinker Diagonal (I 40 W) | 12.3 mi | |
| Continue onto Crosstown Expressway (I 35 S) | 0.9 mi | |
| Keep right towards I 235 North: Oklahoma Health Center | 4.7 mi | |
| Continue towards I 40 West: Amarillo | 64.8 mi | |
| Continue onto Senator Ed Berrong Memorial Highway (I 40 W) | 2.6 mi | |
| Continue onto Korean War Veterans Memorial Highway (I 40 W) | 24.1 mi | |
| Continue onto Great Western Cattle Trail (I 40 W) | 10.6 mi | |
| Continue onto Korean War Veterans Memorial Highway (I 40 W) | 4.2 mi | |
| Turn right onto North Eastern Avenue | 200 feet | |
| Turn left onto East 3rd Street | 1.1 mi | |
| Make a slight left onto US Historic 66 | 6.6 mi | |
| Take the ramp towards I 40 West: Amarillo | 0.4 mi | |
| Merge left onto Korean War Veterans Memorial Highway (I 40 W) | 257.8 mi | |
| Continue onto I 40 | 630.7 mi | |
| Take the ramp towards Stockton Hill Road | 0.4 mi | |
| Turn right onto Stockton Hill Road (CR 20) | 41.5 mi | |
| Turn right onto Pierce Ferry Road (CR 25) | 7.0 mi | |
| Turn right onto Diamond Bar Road | 15.5 mi | |
| Continue onto Buck and Doe Road | 3.2 mi | |
| Turn right onto Quartermaster Point Road | 0.8 mi | |
| Turn right to stay on Quartermaster Point Road | 1.7 mi | |
| You have arrived at your destination |
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Hoover Dam - Grand Canyon