I 65 $south, I 20; I 59 $south
774.2 mi12 hours 47 mins
| Head southwest on North Dixie Street (US 31W) | 400 feet | |
| Turn right onto Main Street (KY 218) | 2.5 mi | |
| Take the ramp on the left | 100 feet | |
| Turn left | 0.4 mi | |
| Merge left onto I 65 S | 90.1 mi | |
| Keep left towards I 24 East: Nashville | 2.4 mi | |
| Keep left towards I 24 East: Chattanooga | 2.8 mi | |
| Keep right towards I 40 West: Memphis | 0.4 mi | |
| Merge left onto I 40 | 0.6 mi | |
| Keep left towards I 65 South: Huntsville | 0.4 mi | |
| Merge right onto I 65 S | 28.8 mi | |
| Keep left onto I-65 (I 65 S) | 66.1 mi | |
| Continue onto I 65 (I 65 S) | 0.2 mi | |
| Continue onto I-65 (I 65 S) | 93.0 mi | |
| Take the ramp towards I 20 West: Tuscaloosa | 0.4 mi | |
| Merge left onto I 20 | 146.0 mi | |
| Continue onto I 20 | 1.8 mi | |
| Keep left towards I 59 South: Laurel | 53.3 mi | |
| Continue onto Lance Corporal Roy M Wheat Memorial Highway (I 59 S) | 106.4 mi | |
| Keep left at the fork | 1.0 mi | |
| Merge right onto I 10 | 29.0 mi | |
| Take the ramp | 0.3 mi | |
| Continue onto I 610 W | 3.8 mi | |
| Keep left at the fork | 0.3 mi | |
| Merge left onto I 10 | 9.7 mi | |
| Take exit 220 towards I 310 South: Boutte | 1.0 mi | |
| Continue onto I 310 S | 9.1 mi | |
| Take the ramp | 0.8 mi | |
| Continue onto 3127 (LA 3127) | 21.9 mi | |
| Turn left onto State Route 20 (LA 20) | 2.2 mi | |
| Keep right onto State Route 20 (LA 20) | 2.7 mi | |
| Continue onto Highway 20 (LA 20) | 9.4 mi | |
| Continue onto North Canal Boulevard (LA 20) | 4.4 mi | |
| Continue onto Main Street (LA 20) | 7.3 mi | |
| Turn left | 400 feet | |
| Take the ramp | 0.3 mi | |
| Merge left onto Raceland-M C Express (US 90 E) | 12.5 mi | |
| Take the ramp towards LA 1: Raceland | 0.3 mi | |
| Turn right onto LA 1 | 2.8 mi | |
| Turn left onto LA 654 | 400 feet | |
| Turn right onto LA 308 | 12.4 mi | |
| Turn right onto lift bridge | 400 feet | |
| Turn left onto LA 1 | 1.3 mi | |
| Turn left onto LA 24 | 0.4 mi | |
| Turn left onto LA 3235 | 16.1 mi | |
| Continue onto LA 1 | 7.9 mi | |
| Turn right to stay on LA 1 Expressway (LA 1) | 8.3 mi | |
| Turn left onto LA 1 | 12.7 mi | |
| Turn left onto Ludwig Lane (LA 574-5) | 800 feet | |
| You have arrived at your destination |
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Horse Cave, Kentucky - Grand Isle, Louisiana