US 65, US 49
443.9 mi8 hours 31 mins
| Head southwest on Convention Boulevard | 500 feet | |
| Turn left onto Malvern Avenue | 5.7 mi | |
| Continue onto Malvern Road (US 270) | 12.7 mi | |
| Continue onto Oliver Lancaster Boulevard (US 270B) | 0.4 mi | |
| Continue onto Martin Luther King Boulevard (US 270B) | 1.3 mi | |
| Continue onto North Main Street (US 270B) | 0.6 mi | |
| Turn left onto East Page Avenue (US 67) | 2.7 mi | |
| Turn right onto US 270 | 39.9 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto I 530 S | 1.0 mi | |
| Take the ramp onto US 65B S | 8.7 mi | |
| Keep right onto US 65B | 900 feet | |
| Keep left onto US 65B | 0.6 mi | |
| Merge left onto I 530 S | 200 feet | |
| Continue onto US 65 | 82.7 mi | |
| Turn right onto US 65 | 35.7 mi | |
| Turn right onto Scarborough Street (US 65) | 27.7 mi | |
| Continue onto North Chestnut Street (US 65) | 1.3 mi | |
| Make a slight right onto Bayou Drive (US 65) | 1.3 mi | |
| Turn left | 0.2 mi | |
| Merge left onto I 20 | 19.4 mi | |
| Merge right onto I 20 | 3.8 mi | |
| Keep right onto I 20 | 39.1 mi | |
| Merge right onto I 20 | 1.7 mi | |
| Keep right onto I 20 | 700 feet | |
| Take the ramp onto US 49 S | 0.5 mi | |
| Keep right onto US 49 S | 77.8 mi | |
| Continue onto US 49 | 4.8 mi | |
| Take the ramp towards I 59 South: New Orleans | 0.3 mi | |
| Merge left towards Mississippi Gulf Coast | 7.8 mi | |
| Take the ramp towards US 98 East: Lucedale | 3.2 mi | |
| Take the ramp towards US 49: Wiggins | 0.3 mi | |
| Keep left towards Multi Purpose Center | 800 feet | |
| Turn right onto US 49 | 58.1 mi | |
| Go straight onto US 49 | 3.6 mi | |
| Turn left onto Pass Road | 400 feet | |
| You have arrived at your destination |
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Hot Springs, Arkansas - Gulfport, Mississippi