US 54, I 72 $east; US 36 $east
194.3 mi3 hours 21 mins
| Head northwest on Rex M Whitton Expressway (US 50 W) | 0.3 mi | |
| Keep right towards US 54 East: Fulton | 48.1 mi | |
| Turn right onto East Liberty Street (US 54) | 10.3 mi | |
| Turn left onto US 54 | 8.1 mi | |
| Turn right to stay on US 54 | 55.5 mi | |
| Turn left onto US 54 | 5.1 mi | |
| Take the ramp on the right towards I 72 East: Springfield | 0.3 mi | |
| Merge left onto I 72 E | 61.9 mi | |
| Take exit 97B towards I 55 Business North: Springfield | 0.4 mi | |
| Keep left towards I 55 Business North: Springfield | 900 feet | |
| Keep right onto I 55 Business | 2.5 mi | |
| Turn right onto East Myrtle Street (I 55 Business) | 0.2 mi | |
| Continue onto South 9th Street (I 55 Business) | 1.3 mi | |
| You have arrived at your destination |
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Jefferson City, Missouri - Springfield, Illinois